Literature DB >> 23784919

Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors.

Tony K M Shing1, Wai-Lung Ng, Judy Y-W Chan, Clara B-S Lau.   

Abstract

Entities:  

Keywords:  SGLT2; allylation; antidiabetics; carbohydrate mimics; diastereoselectivity

Mesh：

Substances：

Year:  2013        PMID： 23784919     DOI： 10.1002/anie.201302543

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  4 in total

1.  Allylic Strain as a Stereocontrol Element in the Hydrogenation of 3-Hydroxymethyl-cyclohex-3-en-1,2,5-triol Derivatives. Synthesis of the Carbasugar Pseudo-2-deoxy-α-D-glucopyranose.

Authors:  Peng Wen; David Crich
Journal:  Tetrahedron       Date:  2018-04-30       Impact factor: 2.457

2.  Synthesis and Evaluation of Oligomeric Thioether-Linked Carbacyclic β-(1→3)-Glucan Mimetics.

Authors:  Peng Wen; Václav Větvička; David Crich
Journal:  J Org Chem       Date:  2019-04-15       Impact factor: 4.354

3.  Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition.

Authors:  Wai-Lung Ng; Ho-Chuen Li; Kit-Man Lau; Anthony K N Chan; Clara Bik-San Lau; Tony K M Shing
Journal:  Sci Rep       Date:  2017-07-17       Impact factor: 4.379

4.  Gram-scale carbasugar synthesis via intramolecular seleno-Michael/aldol reaction.

Authors:  Piotr Banachowicz; Szymon Buda
Journal:  RSC Adv       Date:  2019-04-26       Impact factor: 4.036
  4 in total

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