Literature DB >> 23784135

Pharmacogenomics of Cytauxzoon felis cytochrome b: implications for atovaquone and azithromycin therapy in domestic cats with cytauxzoonosis.

Megan E Schreeg1, Henry S Marr, Jaime Tarigo, Leah A Cohn, Michael G Levy, Adam J Birkenheuer.   

Abstract

Cytauxzoon felis, an emerging virulent protozoan parasite that infects domestic cats, is treated with atovaquone and azithromycin (A&A). Atovaquone targets parasite cytochrome b. We characterized the C. felis cytochrome b gene (cytb) in cats with cytauxzoonosis and found a cytb genotype that was associated with survival in A&A-treated cats.

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Year:  2013        PMID： 23784135      PMCID： PMC3754644          DOI： 10.1128/JCM.01407-13

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  21 in total

1.  Genetic variability of archived Cytauxzoon felis histologic specimens from domestic cats in Georgia, 1995-2007.

Authors:  Holly M Brown; Shirin M Modaresi; Jessica L Cook; Kenneth S Latimer; David S Peterson
Journal:  J Vet Diagn Invest       Date:  2009-07       Impact factor: 1.279

2.  Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites.

Authors:  I K Srivastava; J M Morrisey; E Darrouzet; F Daldal; A B Vaidya
Journal:  Mol Microbiol       Date:  1999-08       Impact factor: 3.501

3.  Atovaquone resistance in malaria parasites.

Authors:  Akhil B. Vaidya; Michael W. Mather
Journal:  Drug Resist Updat       Date:  2000-10       Impact factor: 18.500

4.  Identification and genetic characterization of Cytauxzoon felis in asymptomatic domestic cats and bobcats.

Authors:  Holly M Brown; J Mitchell Lockhart; Kenneth S Latimer; David S Peterson
Journal:  Vet Parasitol       Date:  2010-05-11       Impact factor: 2.738

5.  Molecular detection of Cytauxzoon spp. in asymptomatic Brazilian wild captive felids.

Authors:  Marcos R André; Cristina H Adania; Rosangela Z Machado; Silmara M Allegretti; Paulo A N Felippe; Ketty F Silva; Andréa C H Nakaghi; Ana S Dagnone
Journal:  J Wildl Dis       Date:  2009-01       Impact factor: 1.535

6.  Genetic variability of Cytauxzoon felis from 88 infected domestic cats in Arkansas and Georgia.

Authors:  Holly M Brown; Roy D Berghaus; Kenneth S Latimer; James O Britt; Pauline M Rakich; David S Peterson
Journal:  J Vet Diagn Invest       Date:  2009-01       Impact factor: 1.279

Review 7.  Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer.

Authors:  Zuben E Sauna; Chava Kimchi-Sarfaty; Suresh V Ambudkar; Michael M Gottesman
Journal:  Cancer Res       Date:  2007-10-15       Impact factor: 12.701

8.  Cytauxzoon felis infection in cats in the mid-Atlantic states: 34 cases (1998-2004).

Authors:  Adam J Birkenheuer; Jaime A Le; Amy M Valenzisi; Melissa D Tucker; Michael G Levy; Edward B Breitschwerdt
Journal:  J Am Vet Med Assoc       Date:  2006-02-15       Impact factor: 1.936

9.  Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection.

Authors:  Gary P Wormser; Aakanksha Prasad; Ellen Neuhaus; Samit Joshi; John Nowakowski; John Nelson; Abraham Mittleman; Maria Aguero-Rosenfeld; Jeffrey Topal; Peter J Krause
Journal:  Clin Infect Dis       Date:  2010-02-01       Impact factor: 9.079

Review 10.  Extrachromosomal DNA in the Apicomplexa.

Authors:  R J Wilson; D H Williamson
Journal:  Microbiol Mol Biol Rev       Date:  1997-03       Impact factor: 11.056
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  4 in total

Review 1.  Two Tales of Cytauxzoon felis Infections in Domestic Cats.

Authors:  Jin-Lei Wang; Ting-Ting Li; Guo-Hua Liu; Xing-Quan Zhu; Chaoqun Yao
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132

2.  Rapid High-Resolution Melt Analysis of Cytauxzoon felis Cytochrome b To Aid in the Prognosis of Cytauxzoonosis.

Authors:  Megan E Schreeg; Henry S Marr; Jaime L Tarigo; Leah A Cohn; Michael G Levy; Adam J Birkenheuer
Journal:  J Clin Microbiol       Date:  2015-05-27       Impact factor: 5.948

3.  Molecular analysis of blood-associated pathogens in European wildcats (Felis silvestris silvestris) from Germany.

Authors:  Maria Sophia Unterköfler; Josef Harl; Bita Shahi Barogh; Joachim Spergser; Kristýna Hrazdilová; Franz Müller; Diana Jeschke; Ole Anders; Peter Steinbach; Hermann Ansorge; Hans-Peter Fuehrer; Mike Heddergott
Journal:  Int J Parasitol Parasites Wildl       Date:  2022-09-03       Impact factor: 2.773

4.  Cytauxzoon felis cytochrome b gene mutation associated with atovaquone and azithromycin treatment.

Authors:  Ashley N Hartley; Henry S Marr; Adam J Birkenheuer
Journal:  J Vet Intern Med       Date:  2020-11-04       Impact factor: 3.333
  4 in total

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