Literature DB >> 2378349

A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype.

C I Amos1, R C Elston, G E Bonney, B J Keats, G S Berenson.   

Abstract

The robust or model-free method for detecting linkage developed by Haseman and Elston for data from sib pairs is extended to incorporate observations of multiple traits on each individual. A method is proposed that estimates the linear function that results in the strongest correlation between the squared pair differences in the trait measurements and identity by descent at a marker locus. The method is illustrated by the study of apolipoprotein and cholesterol levels in individuals from a large family that had many members diagnosed with coronary heart disease.

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Year:  1990        PMID： 2378349      PMCID： PMC1683708     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  22 in total

1.  Testing association of metric traits and marker genes.

Authors:  D C LOWRY; F T SHULTZ
Journal:  Ann Hum Genet       Date:  1959-04       Impact factor: 1.670

2.  Quantitative linkage: a statistical procedure for its detection and estimation.

Authors:  A P Hill
Journal:  Ann Hum Genet       Date:  1975-05       Impact factor: 1.670

3.  Bivariate analyses of cholesterol and triglyceride levels in families in which probands have type IIb lipoprotein phenotype.

Authors:  K K Namboodiri; R C Elston; C J Glueck; R Fallat; C R Buncher; R Tsang
Journal:  Am J Hum Genet       Date:  1975-07       Impact factor: 11.025

4.  On the detection and estimation of linkage between a locus influencing a quantitative character and a marker locus.

Authors:  S D Jayakar
Journal:  Biometrics       Date:  1970-09       Impact factor: 2.571

5.  Pedigree discriminant analysis: a method to identify monogenic segregation.

Authors:  L H Zlotnik; R C Elston; K K Namboodiri
Journal:  Am J Med Genet       Date:  1983-06

6.  Extensions to pedigree analysis. IV. Covariance components models for multivariate traits.

Authors:  K Lange; M Boehnke
Journal:  Am J Med Genet       Date:  1983-03

7.  Genetics of LCAT (lecithin: cholesterol acyltransferase) deficiency.

Authors:  P Teisberg; E Gjone; B Olaisen
Journal:  Ann Hum Genet       Date:  1975-01       Impact factor: 1.670

8.  Genetic control of lecithin-cholesterol acyltransferase (LCAT): measurement of LCAT mass in a large kindred with LCAT deficiency.

Authors:  J J Albers; G Utermann
Journal:  Am J Hum Genet       Date:  1981-09       Impact factor: 11.025

9.  Study of the genetic transmission of hypercholesterolemia and hypertriglyceridemia in a 195 member kindred.

Authors:  R C Elston; K K Namboodiri; C J Glueck; R Fallat; R Tsang; V Leuba
Journal:  Ann Hum Genet       Date:  1975-07       Impact factor: 1.670

10.  Genetic analysis of von Willebrand's disease in two large pedigrees: a multivariate approach.

Authors:  L R Goldin; R C Elston; J B Graham; C H Miller
Journal:  Am J Med Genet       Date:  1980
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  20 in total

1.  Enhanced efficiency of quantitative trait loci mapping analysis based on multivariate complexes of quantitative traits.

Authors:  A B Korol; Y I Ronin; A M Itskovich; J Peng; E Nevo
Journal:  Genetics       Date:  2001-04       Impact factor: 4.562

2.  Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results.

Authors:  J T Williams; P Van Eerdewegh; L Almasy; J Blangero
Journal:  Am J Hum Genet       Date:  1999-10       Impact factor: 11.025

3.  Use of multivariate linkage analysis for dissection of a complex cognitive trait.

Authors:  Angela J Marlow; Simon E Fisher; Clyde Francks; I Laurence MacPhie; Stacey S Cherny; Alex J Richardson; Joel B Talcott; John F Stein; Anthony P Monaco; Lon R Cardon
Journal:  Am J Hum Genet       Date:  2003-02-13       Impact factor: 11.025

4.  Multivariate analysis of quantitative trait loci influencing variation in anxiety-related behavior in laboratory mice.

Authors:  Maria Grazia Turri; John C DeFries; Norman D Henderson; Jonathan Flint
Journal:  Mamm Genome       Date:  2004-02       Impact factor: 2.957

5.  Robust estimation of experimentwise P values applied to a genome scan of multiple asthma traits identifies a new region of significant linkage on chromosome 20q13.

Authors:  Manuel A R Ferreira; Louise O'Gorman; Peter Le Souëf; Paul R Burton; Brett G Toelle; Colin F Robertson; Peter M Visscher; Nicholas G Martin; David L Duffy
Journal:  Am J Hum Genet       Date:  2005-10-14       Impact factor: 11.025

6.  Quantitative trait locus analysis of longitudinal quantitative trait data in complex pedigrees.

Authors:  Stuart Macgregor; Sara A Knott; Ian White; Peter M Visscher
Journal:  Genetics       Date:  2005-07-14       Impact factor: 4.562

Review 7.  Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles.

Authors:  Hemant K Tiwari; Jill Barnholtz-Sloan; Nathan Wineinger; Miguel A Padilla; Laura K Vaughan; David B Allison
Journal:  Hum Hered       Date:  2008-03-31       Impact factor: 0.444

8.  Using multivariate genetic modeling to detect pleiotropic quantitative trait loci.

Authors:  D I Boomsma
Journal:  Behav Genet       Date:  1996-03       Impact factor: 2.805

9.  Univariate/multivariate genome-wide association scans using data from families and unrelated samples.

Authors:  Lei Zhang; Yu-Fang Pei; Jian Li; Christopher J Papasian; Hong-Wen Deng
Journal:  PLoS One       Date:  2009-08-04       Impact factor: 3.240

10.  Family-based bivariate association tests for quantitative traits.

Authors:  Lei Zhang; Aaron J Bonham; Jian Li; Yu-Fang Pei; Jie Chen; Christopher J Papasian; Hong-Wen Deng
Journal:  PLoS One       Date:  2009-12-02       Impact factor: 3.240
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