Literature DB >> 23782398

N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.

Gang Lin1, Tamutenda Chidawanyika, Christopher Tsu, Thulasi Warrier, Julien Vaubourgeix, Christopher Blackburn, Kenneth Gigstad, Michael Sintchak, Lawrence Dick, Carl Nathan.   

Abstract

We identified N,C-capped dipeptides that are selective for the Mycobacterium tuberculosis proteasome over human constitutive and immunoproteasomes. Differences in the S3 and S1 binding pockets appeared to account for the species selectivity. The inhibitors can penetrate mycobacteria and kill nonreplicating M. tuberculosis under nitrosative stress.

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Year:  2013        PMID： 23782398      PMCID： PMC3773049          DOI： 10.1021/ja400021x

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  18 in total

Review 1.  Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme.

Authors:  Elke Krüger; Peter-M Kloetzel
Journal:  Curr Opin Immunol       Date:  2012-01-31       Impact factor: 7.486

2.  Role of iNOS in human host defense.

Authors:  Carl Nathan
Journal:  Science       Date:  2006-06-30       Impact factor: 47.728

3.  A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC.

Authors:  R Glynne; S H Powis; S Beck; A Kelly; L A Kerr; J Trowsdale
Journal:  Nature       Date:  1991-09-26       Impact factor: 49.962

Review 4.  The proteasome: paradigm of a self-compartmentalizing protease.

Authors:  W Baumeister; J Walz; F Zühl; E Seemüller
Journal:  Cell       Date:  1998-02-06       Impact factor: 41.582

5.  Identification of nitric oxide synthase as a protective locus against tuberculosis.

Authors:  J D MacMicking; R J North; R LaCourse; J S Mudgett; S K Shah; C F Nathan
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

6.  Second proteasome-related gene in the human MHC class II region.

Authors:  A Kelly; S H Powis; R Glynne; E Radley; S Beck; J Trowsdale
Journal:  Nature       Date:  1991-10-17       Impact factor: 49.962

7.  The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide.

Authors:  K Heran Darwin; Sabine Ehrt; José-Carlos Gutierrez-Ramos; Nadine Weich; Carl F Nathan
Journal:  Science       Date:  2003-12-12       Impact factor: 47.728

8.  Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity.

Authors:  Gang Lin; Guiqing Hu; Christopher Tsu; Yune Z Kunes; Huilin Li; Lawrence Dick; Thomas Parsons; Ping Li; Zhiqiang Chen; Peter Zwickl; Nadine Weich; Carl Nathan
Journal:  Mol Microbiol       Date:  2006-03       Impact factor: 3.501

9.  Selective killing of nonreplicating mycobacteria.

Authors:  Ruslana Bryk; Benjamin Gold; Aditya Venugopal; Jasbir Singh; Raghu Samy; Krzysztof Pupek; Hua Cao; Carmen Popescu; Mark Gurney; Srinivas Hotha; Joseph Cherian; Kyu Rhee; Lan Ly; Paul J Converse; Sabine Ehrt; Omar Vandal; Xiuju Jiang; Jean Schneider; Gang Lin; Carl Nathan
Journal:  Cell Host Microbe       Date:  2008-03-13       Impact factor: 21.023

10.  In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice.

Authors:  Sheetal Gandotra; Dirk Schnappinger; Mercedes Monteleone; Wolfgang Hillen; Sabine Ehrt
Journal:  Nat Med       Date:  2007-12-02       Impact factor: 53.440
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  27 in total

1.  Discovery of new Mycobacterium tuberculosis proteasome inhibitors using a knowledge-based computational screening approach.

Authors:  Rukmankesh Mehra; Reena Chib; Gurunadham Munagala; Kushalava Reddy Yempalla; Inshad Ali Khan; Parvinder Pal Singh; Farrah Gul Khan; Amit Nargotra
Journal:  Mol Divers       Date:  2015-08-01       Impact factor: 2.943

2.  Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2).

Authors:  Lin Bai; Jordan B Jastrab; Marta Isasa; Kuan Hu; Hongjun Yu; Steven P Gygi; K Heran Darwin; Huilin Li
Journal:  J Bacteriol       Date:  2017-04-11       Impact factor: 3.490

3.  Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors.

Authors:  Wenhu Zhan; Joseph Visone; Tierra Ouellette; Jacob C Harris; Rong Wang; Hao Zhang; Pradeep K Singh; John Ginn; George Sukenick; Tzu-Tshin Wong; Judith I Okoro; Ryan M Scales; Patrick K Tumwebaze; Philip J Rosenthal; Björn F C Kafsack; Roland A Cooper; Peter T Meinke; Laura A Kirkman; Gang Lin
Journal:  J Med Chem       Date:  2019-06-20       Impact factor: 7.446

4.  Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.

Authors:  Kyle A Totaro; Dominik Barthelme; Peter T Simpson; Xiuju Jiang; Gang Lin; Carl F Nathan; Robert T Sauer; Jason K Sello
Journal:  ACS Infect Dis       Date:  2016-12-05       Impact factor: 5.084

5.  Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome.

Authors:  Wenhu Zhan; Hao-Chi Hsu; Trevor Morgan; Tierra Ouellette; Kristin Burns-Huang; Ryoma Hara; Adrian G Wright; Toshihiro Imaeda; Rei Okamoto; Kenjiro Sato; Mayako Michino; Manoj Ramjee; Kazuyoshi Aso; Peter T Meinke; Michael Foley; Carl F Nathan; Huilin Li; Gang Lin
Journal:  J Med Chem       Date:  2019-10-15       Impact factor: 7.446

6.  Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.

Authors:  Hao-Chi Hsu; Pradeep K Singh; Hao Fan; Rong Wang; George Sukenick; Carl Nathan; Gang Lin; Huilin Li
Journal:  Biochemistry       Date:  2016-12-27       Impact factor: 3.162

7.  Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.

Authors:  Esilida Sula Karreci; Hao Fan; Mayuko Uehara; Albana B Mihali; Pradeep K Singh; Ahmed T Kurdi; Zhabiz Solhjou; Leonardo V Riella; Irene Ghobrial; Teresina Laragione; Sujit Routray; Jean Pierre Assaker; Rong Wang; George Sukenick; Lei Shi; Franck J Barrat; Carl F Nathan; Gang Lin; Jamil Azzi
Journal:  Proc Natl Acad Sci U S A       Date:  2016-12-12       Impact factor: 11.205

8.  Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome.

Authors:  Hao Fan; Nicholas G Angelo; J David Warren; Carl F Nathan; Gang Lin
Journal:  ACS Med Chem Lett       Date:  2014-02-03       Impact factor: 4.345

9.  Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors.

Authors:  Pradeep K Singh; Hao Fan; Xiuju Jiang; Lei Shi; Carl F Nathan; Gang Lin
Journal:  ChemMedChem       Date:  2016-08-25       Impact factor: 3.466

Review 10.  Prokaryotic ubiquitin-like protein modification.

Authors:  Julie A Maupin-Furlow
Journal:  Annu Rev Microbiol       Date:  2014-05-29       Impact factor: 15.500
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