Gwan Gyu Song1, Young Ho Lee. 1. Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul 136-705, Korea.
Abstract
OBJECTIVE: The aim of this study was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) and monocyte chemoattractant protein-1 (MCP-1) polymorphisms confer susceptibility to systemic sclerosis (SSc). METHODS: MEDLINE and manual search were utilized to identify available articles. A meta-analysis was conducted on the associations between the CTLA-4 +49 A/G, -318 C/T, -1661 A/G, and -1722 C/T, and MCP-1 -2518 A/G polymorphisms, using a fixed-effect or random-effect model based on between-study heterogeneity. RESULTS: Eleven comparative studies involving 959 SSc patients and 1739 controls were included in the meta-analysis. No association was found between SSc and the CTLA-4 +49 A/G polymorphism (OR for the +49 G allele = 1.032, 95% CI = 0.830-1.283, p = 0.779). However, an association between SSc and the CTLA-4 -318 TT + TC genotype (OR = 1.642, 95% CI = 1.034-2.609, p = 0.036). Meta-analyses failed to reveal an association between SSc and CTLA-4 -1722 C/T, MCP-1 -2518 A/G polymorphisms. CONCLUSIONS: This meta-analysis of published data shows that the CTLA-4 -318 C/T polymorphism confers susceptibility to SSc.
OBJECTIVE: The aim of this study was to explore whether cytotoxic T lymphocyte antigen-4 (CTLA-4) and monocyte chemoattractant protein-1 (MCP-1) polymorphisms confer susceptibility to systemic sclerosis (SSc). METHODS: MEDLINE and manual search were utilized to identify available articles. A meta-analysis was conducted on the associations between the CTLA-4+49 A/G, -318 C/T, -1661 A/G, and -1722 C/T, and MCP-1-2518 A/G polymorphisms, using a fixed-effect or random-effect model based on between-study heterogeneity. RESULTS: Eleven comparative studies involving 959 SSc patients and 1739 controls were included in the meta-analysis. No association was found between SSc and the CTLA-4+49 A/G polymorphism (OR for the +49 G allele = 1.032, 95% CI = 0.830-1.283, p = 0.779). However, an association between SSc and the CTLA-4 -318 TT + TC genotype (OR = 1.642, 95% CI = 1.034-2.609, p = 0.036). Meta-analyses failed to reveal an association between SSc and CTLA-4-1722 C/T, MCP-1-2518 A/G polymorphisms. CONCLUSIONS: This meta-analysis of published data shows that the CTLA-4-318 C/T polymorphism confers susceptibility to SSc.