Literature DB >> 23780721

Nickel-mediated radioiodination of aryl and heteroaryl bromides: rapid synthesis of tracers for SPECT imaging.

Alastair A Cant1, Sue Champion, Rajiv Bhalla, Sally L Pimlott, Andrew Sutherland.   

Abstract

Rapid and efficient radioiodination of aryl and heteroaryl bromides has been achieved using a nickel(0)-mediated halogen-exchange reaction. This transformation gives direct access to [(123)I]- and [(125)I]-imaging agents for single photon emission computed tomography (SPECT), such as 5-[(123)I]-A85380 (see scheme, Boc = tert-butyloxycarbonyl, cod = 1,5-cyclooctadiene, TFA = trifluoroacetic acid).
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  aryl bromides; halogen exchange; imaging agents; nickel; radioiodination

Mesh：

Substances：

Year:  2013        PMID： 23780721     DOI： 10.1002/anie.201302800

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  6 in total

1.  Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

Authors:  François Guérard; Yong-Sok Lee; Kwamena Baidoo; Jean-François Gestin; Martin W Brechbiel
Journal:  Chemistry       Date:  2016-06-15       Impact factor: 5.236

2.  A novel 18F-labelled high affinity agent for PET imaging of the translocator protein.

Authors:  Adele Blair; Filip Zmuda; Gaurav Malviya; Adriana A S Tavares; Gilles D Tamagnan; Anthony J Chalmers; Deborah Dewar; Sally L Pimlott; Andrew Sutherland
Journal:  Chem Sci       Date:  2015-05-27       Impact factor: 9.825

Review 3.  Applications of Magnetic Particle Imaging in Biomedicine: Advancements and Prospects.

Authors:  Xue Yang; Guoqing Shao; Yanyan Zhang; Wei Wang; Yu Qi; Shuai Han; Hongjun Li
Journal:  Front Physiol       Date:  2022-07-01       Impact factor: 4.755

4.  Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes.

Authors:  Stacey Webster; Kerry M O'Rourke; Conor Fletcher; Sally L Pimlott; Andrew Sutherland; Ai-Lan Lee
Journal:  Chemistry       Date:  2017-12-14       Impact factor: 5.236

Review 5.  Metal-Mediated Halogen Exchange in Aryl and Vinyl Halides: A Review.

Authors:  Gwilherm Evano; Antoine Nitelet; Pierre Thilmany; Damien F Dewez
Journal:  Front Chem       Date:  2018-04-26       Impact factor: 5.221

6.  Orthogonal Stability and Reactivity of Aryl Germanes Enables Rapid and Selective (Multi)Halogenations.

Authors:  Christoph Fricke; Kristina Deckers; Franziska Schoenebeck
Journal:  Angew Chem Int Ed Engl       Date:  2020-08-20       Impact factor: 16.823
  6 in total

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