INTRODUCTION: Magnetic resonance enterography (MRE) is believed to be a reliable diagnostic method in assessing the activity of small-bowel Crohn's disease (CD). However, there are no scales for quantifying MRE scores that could be used in everyday clinical practice. OBJECTIVES: The aim of the study was to construct a simple scale for assessing the activity of CD (Simple Enterographic Activity Score for Crohn's Disease - SEAS-CD) in MRE and to investigate its clinical usefulness. PATIENTS AND METHODS: We conducted a retrospective analysis of MRE findings in 122 patients with CD. Disease activity was assessed using the SEAS-CD. The reference standard was endoscopic assessment using the Simple Endoscopic Score for Crohn's Disease (SES-CD). We assessed correlations between SEAS-CD and endoscopic, clinical, and biochemical findings. We also proposed the Global Crohn's Disease Activity Score to assess total CD activity by summarizing the colonic SES-CD and SEAS-CD scores. RESULTS: In the validation group (n = 62), a significant correlation between the ileal SES-CD and ileal SEAS-CD scores was noted (r = 0.72, P <0.0001). In patients with isolated small-bowel CD, there was a significant correlation between SEAS-CD and Crohn's Disease Activity Index (CDAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), hemoglobin (Hb), albumin, and platelet count. In patients with ileocolonic CD, the Global Crohn's Disease Activity Score correlated with CDAI, CRP, ESR, Hb, and hematocrit. CONCLUSIONS: SEAS-CD is a useful tool for the quantification of small-bowel CD activity assessed by MRE. The Global Crohn's Disease Activity Score may be useful in assessing the progression of lesions in patients with ileocolonic CD.
INTRODUCTION: Magnetic resonance enterography (MRE) is believed to be a reliable diagnostic method in assessing the activity of small-bowel Crohn's disease (CD). However, there are no scales for quantifying MRE scores that could be used in everyday clinical practice. OBJECTIVES: The aim of the study was to construct a simple scale for assessing the activity of CD (Simple Enterographic Activity Score for Crohn's Disease - SEAS-CD) in MRE and to investigate its clinical usefulness. PATIENTS AND METHODS: We conducted a retrospective analysis of MRE findings in 122 patients with CD. Disease activity was assessed using the SEAS-CD. The reference standard was endoscopic assessment using the Simple Endoscopic Score for Crohn's Disease (SES-CD). We assessed correlations between SEAS-CD and endoscopic, clinical, and biochemical findings. We also proposed the Global Crohn's Disease Activity Score to assess total CD activity by summarizing the colonic SES-CD and SEAS-CD scores. RESULTS: In the validation group (n = 62), a significant correlation between the ileal SES-CD and ileal SEAS-CD scores was noted (r = 0.72, P <0.0001). In patients with isolated small-bowel CD, there was a significant correlation between SEAS-CD and Crohn's Disease Activity Index (CDAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), hemoglobin (Hb), albumin, and platelet count. In patients with ileocolonic CD, the Global Crohn's Disease Activity Score correlated with CDAI, CRP, ESR, Hb, and hematocrit. CONCLUSIONS:SEAS-CD is a useful tool for the quantification of small-bowel CD activity assessed by MRE. The Global Crohn's Disease Activity Score may be useful in assessing the progression of lesions in patients with ileocolonic CD.
Authors: Piotr Eder; Michal Michalak; Katarzyna Katulska; Liliana Lykowska-Szuber; Iwona Krela-Kazmierczak; Kamila Stawczyk-Eder; Katarzyna Klimczak; Aleksandra Szymczak; Krzysztof Linke Journal: Sci Rep Date: 2015-05-20 Impact factor: 4.379
Authors: Piotr Eder; Katarzyna Katulska; Iwona Krela-Kaźmierczak; Kamila Stawczyk-Eder; Katarzyna Klimczak; Aleksandra Szymczak; Krzysztof Linke; Liliana Łykowska-Szuber Journal: Abdom Imaging Date: 2015-10
Authors: Kamila Stawczyk-Eder; Piotr Eder; Liliana Lykowska-Szuber; Iwona Krela-Kazmierczak; Katarzyna Klimczak; Aleksandra Szymczak; Patrycja Szachta; Katarzyna Katulska; Krzysztof Linke Journal: Arch Med Sci Date: 2015-04-23 Impact factor: 3.318
Authors: Piotr Eder; Liliana Łykowska-Szuber; Katarzyna Katulska; Kamila Stawczyk-Eder; Iwona Krela-Kaźmierczak; Katarzyna Klimczak; Aleksandra Szymczak; Marek Stajgis; Krzysztof Linke Journal: Prz Gastroenterol Date: 2015-11-04