Karen A Eley1, Stephen R Watt-Smith2, Paul Boland3, Matthew Potter4, Stephen J Golding5. 1. Nuffield Department of Surgical Sciences, University of Oxford, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. Electronic address: Karen.a.eley@gmail.com. 2. Nuffield Department of Surgical Sciences, University of Oxford, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. Electronic address: Steve.watt-smith@ndm.ox.ac.uk. 3. Nuffield Department of Surgical Sciences, University of Oxford, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. Electronic address: Paul.william.boland@gmail.com. 4. Department of Plastic Surgery, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. Electronic address: mattpotters@hotmail.com. 5. Nuffield Department of Surgical Sciences, University of Oxford, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. Electronic address: Stephen.golding@nds.ox.ac.uk.
Abstract
UNLABELLED: Tumour volume (Tv) measurements obtained from pre-treatment CT and MRI have increasingly shown to be more reliable predictors of outcome than TNM stage. The aim of this study was to determine the correlation of MRI calculated maxillary complex tumour volume with patient outcome. METHODS: The medical records of 39 patients with squamous cell carcinoma involving the maxillary sinus, maxilla, hard palate and maxillary alveolus were reviewed and tumour volume measurements completed on pre-treatment MRI. RESULTS: The mean tumour volume was 12.79 ± 24.31 cm(3). Independent samples t test was significant for increasing overall all-cause survival and decreasing tumour volume (1 year: p = 0.003; 5-year: p = 0.031). Cox regression was significant for stratified tumour volume, nodal involvement and peri-neural invasion for predicting disease-free survival. CONCLUSIONS: MRI measured tumour volume assessment appears to be a reliable predictor of survival in patients with maxillary complex SCC treated by surgical resection.
UNLABELLED: Tumour volume (Tv) measurements obtained from pre-treatment CT and MRI have increasingly shown to be more reliable predictors of outcome than TNM stage. The aim of this study was to determine the correlation of MRI calculated maxillary complex tumour volume with patient outcome. METHODS: The medical records of 39 patients with squamous cell carcinoma involving the maxillary sinus, maxilla, hard palate and maxillary alveolus were reviewed and tumour volume measurements completed on pre-treatment MRI. RESULTS: The mean tumour volume was 12.79 ± 24.31 cm(3). Independent samples t test was significant for increasing overall all-cause survival and decreasing tumour volume (1 year: p = 0.003; 5-year: p = 0.031). Cox regression was significant for stratified tumour volume, nodal involvement and peri-neural invasion for predicting disease-free survival. CONCLUSIONS: MRI measured tumour volume assessment appears to be a reliable predictor of survival in patients with maxillary complex SCC treated by surgical resection.
Authors: Olena Klymenko; Anna Maria Stefanie Buchberger; Barbara Wollenberg; Klaus-Dietrich Wolff; Victoria Kehl; Stephanie E Combs; Anja Pickhard; Steffi U Pigorsch Journal: Cancers (Basel) Date: 2021-05-14 Impact factor: 6.639
Authors: João Pedro Perez Gomes; José de Ribamar Castro Veloso; Albina Messias de Almeida M Altemani; Carlos Takahiro Chone; João Mauricio Carrasco Altemani; Claudio Fróes de Freitas; Carmen Silvia Passos Lima; Paulo Henrique Braz-Silva; Andre Luiz Ferreira Costa Journal: Am J Case Rep Date: 2018-10-02