| Literature DB >> 23777778 |
Christine Yang1, Hong C Shen, Zhicai Wu, Hong D Chu, Jason M Cox, Jaume Balsells, Alejandro Crespo, Patricia Brown, Beata Zamlynny, Judyann Wiltsie, Joseph Clemas, Jack Gibson, Lisa Contino, Jeanmarie Lisnock, Gaochao Zhou, Margarita Garcia-Calvo, Tom Bateman, Ling Xu, Xinchun Tong, Martin Crook, Peter Sinclair.
Abstract
Novel oxazolidinedione analogs were discovered as potent and selective mineralocorticoid receptor (MR) antagonists. Structure-activity relationship (SAR) studies were focused on improving the potency and microsomal stability. Selected compounds demonstrated excellent MR activity, reasonable nuclear hormone receptor selectivity, and acceptable rat pharmacokinetics.Entities:
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Year: 2013 PMID： 23777778 DOI： 10.1016/j.bmcl.2013.05.077
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823