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Literature DB >> 23776159

Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete.

Kyoung Hwa Jang¹, Sang-Jip Nam, Jeffrey B Locke, Christopher A Kauffman, Deanna S Beatty, Lauren A Paul, William Fenical.

Abstract

Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.

Entities: CellLine Chemical Disease Gene Species

Keywords: anthrax; antibiotics; bacillus anthracis; natural products; polyketides

Mesh：

Substances：

Year: 2013 PMID： 23776159 PMCID： PMC3821700 DOI： 10.1002/anie.201302749

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

2 in total

1. The total synthesis of chlorotonil A.

Authors: Nicola Rahn; Markus Kalesse
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

2. Chlorotonil A, a macrolide with a unique gem-dichloro-1,3-dione functionality from Sorangium cellulosum, So ce1525.

Authors: Klaus Gerth; Heinrich Steinmetz; Gerhard Höfle; Rolf Jansen
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

2 in total

36 in total

1. Asymmetric Total Synthesis of the Naturally Occurring Antibiotic Anthracimycin.

Authors: Emma K Davison; Jared L Freeman; Wanli Zhang; William M Wuest; Daniel P Furkert; Margaret A Brimble
Journal: Org Lett Date: 2020-06-29 Impact factor: 6.005

2. Biosynthetic origin of anthracimycin: a tricyclic macrolide from Streptomyces sp.

Authors: Enjuro Harunari; Hisayuki Komaki; Yasuhiro Igarashi
Journal: J Antibiot (Tokyo) Date: 2015-12-02 Impact factor: 2.649

Review 3. Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products.

Authors: Keshav K Nepal; Guojun Wang
Journal: Biotechnol Adv Date: 2018-10-09 Impact factor: 14.227

4. The 160K Natural Organism Library, a unique resource for natural products research.

Authors: Siew Bee Ng; Yoganathan Kanagasundaram; Hao Fan; Prakash Arumugam; Birgit Eisenhaber; Frank Eisenhaber
Journal: Nat Biotechnol Date: 2018-07-06 Impact factor: 54.908

5. Synergistic interactions of vancomycin with different antibiotics against Escherichia coli: trimethoprim and nitrofurantoin display strong synergies with vancomycin against wild-type E. coli.

Authors: Alice Zhou; Tina Manzhu Kang; Jessica Yuan; Casey Beppler; Caroline Nguyen; Zhiyuan Mao; Minh Quan Nguyen; Pamela Yeh; Jeffrey H Miller
Journal: Antimicrob Agents Chemother Date: 2014-10-27 Impact factor: 5.191

10. Actinoquinolines A and B, anti-inflammatory quinoline alkaloids from a marine-derived Streptomyces sp., strain CNP975.

Authors: Hossam M Hassan; Chollaratt Boonlarppradab; William Fenical
Journal: J Antibiot (Tokyo) Date: 2016-05-25 Impact factor: 2.649

Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete.

1. The total synthesis of chlorotonil A.

2. Chlorotonil A, a macrolide with a unique gem-dichloro-1,3-dione functionality from Sorangium cellulosum, So ce1525.

1. Asymmetric Total Synthesis of the Naturally Occurring Antibiotic Anthracimycin.

2. Biosynthetic origin of anthracimycin: a tricyclic macrolide from Streptomyces sp.

Review 3. Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products.

4. The 160K Natural Organism Library, a unique resource for natural products research.

5. Synergistic interactions of vancomycin with different antibiotics against Escherichia coli: trimethoprim and nitrofurantoin display strong synergies with vancomycin against wild-type E. coli.

Review 6. Designing inhibitors of anthrax toxin.

7. Antimalarial activity of the myxobacterial macrolide chlorotonil a.

8. Production of macrolide antibiotics from a cytotoxic soil Streptomyces sp. strain ZDB.

Review 9. Antimicrobial compounds from marine actinomycetes.

10. Actinoquinolines A and B, anti-inflammatory quinoline alkaloids from a marine-derived Streptomyces sp., strain CNP975.