OBJECTIVES: To describe three cases of cryptococcus neoformans meningitis and evaluate their cellular immunity. METHODS: This study involved three cases of cryptococcus neoformans meningitis admitted to Children's Hospital of Shanxi Province between July 2010 and July 2011. Clinical presentations, laboratory findings, treatment and outcome in these cases has been discussed. RESULTS: Staining cerebrospinal fluid (CSF) with India ink showed Cryptococcus neoformans. Flow cytometric analysis of T-cell subsets revealed that their cellular immunity were depressed, which mainly embodies decline in CD4+ levels. CONCLUSIONS: The authors speculate that decreased CD4+ T lymphocyte counts are attributed to cryptococcal infection, emphasizing the significance and importance of evaluating cellular immunity in patients who present with unusual infections. Early diagnosis of cryptococcal meningitis and appropriate antifungal therapy are essential to achieve a better outcome.
OBJECTIVES: To describe three cases of cryptococcus neoformansmeningitis and evaluate their cellular immunity. METHODS: This study involved three cases of cryptococcus neoformansmeningitis admitted to Children's Hospital of Shanxi Province between July 2010 and July 2011. Clinical presentations, laboratory findings, treatment and outcome in these cases has been discussed. RESULTS: Staining cerebrospinal fluid (CSF) with India ink showed Cryptococcus neoformans. Flow cytometric analysis of T-cell subsets revealed that their cellular immunity were depressed, which mainly embodies decline in CD4+ levels. CONCLUSIONS: The authors speculate that decreased CD4+ T lymphocyte counts are attributed to cryptococcal infection, emphasizing the significance and importance of evaluating cellular immunity in patients who present with unusual infections. Early diagnosis of cryptococcal meningitis and appropriate antifungal therapy are essential to achieve a better outcome.
Authors: Norlijah Othman; Nor Atiqah Ng Abdullah; Zubaidah Abdul Wahab Journal: Southeast Asian J Trop Med Public Health Date: 2004-12 Impact factor: 0.267
Authors: Wieland Meyer; Alexandra Castañeda; Stuart Jackson; Matthew Huynh; Elizabeth Castañeda Journal: Emerg Infect Dis Date: 2003-02 Impact factor: 6.883
Authors: John R Perfect; William E Dismukes; Francoise Dromer; David L Goldman; John R Graybill; Richard J Hamill; Thomas S Harrison; Robert A Larsen; Olivier Lortholary; Minh-Hong Nguyen; Peter G Pappas; William G Powderly; Nina Singh; Jack D Sobel; Tania C Sorrell Journal: Clin Infect Dis Date: 2010-02-01 Impact factor: 9.079