BACKGROUND/AIMS: To assess the impact of mild cognitive impairment (MCI) or cognitive decline on health-related quality of life (HR-QOL) in Parkinson's disease (PD). METHODS: HR-QOL measured by the Parkinson Disease Quality of Life Questionnaire (PDQ-39), MCI according to Movement Disorder Society Task Force criteria and cognitive decline from premorbid baseline were assessed in non-demented PD patients at 6 movement disorder clinics. RESULTS: Among 137 patients, after adjusting for education, gender, disease duration, and Movement Disorder Society Unified Parkinson's Disease Rating Scale total score, MCI was associated with worse scores within the PDQ-39 dimension of communication (p = 0.008). Subjects were divided into tertiles of cognitive decline from premorbid level. Scores in the dimension of stigma were worst in the second tertile of cognitive decline (p = 0.03). MCI was associated with worse social support scores in the second tertile of cognitive decline (p = 0.008). CONCLUSION: MCI and cognitive decline from premorbid baseline are associated with reduced HR-QOL in communication, stigma, and social support domains. The cognitive decline from premorbid baseline modifies the association between MCI and HR-QOL in PD and knowing both will allow a better appreciation of difficulties patients face in daily life.
BACKGROUND/AIMS: To assess the impact of mild cognitive impairment (MCI) or cognitive decline on health-related quality of life (HR-QOL) in Parkinson's disease (PD). METHODS: HR-QOL measured by the Parkinson Disease Quality of Life Questionnaire (PDQ-39), MCI according to Movement Disorder Society Task Force criteria and cognitive decline from premorbid baseline were assessed in non-demented PDpatients at 6 movement disorder clinics. RESULTS: Among 137 patients, after adjusting for education, gender, disease duration, and Movement Disorder Society Unified Parkinson's Disease Rating Scale total score, MCI was associated with worse scores within the PDQ-39 dimension of communication (p = 0.008). Subjects were divided into tertiles of cognitive decline from premorbid level. Scores in the dimension of stigma were worst in the second tertile of cognitive decline (p = 0.03). MCI was associated with worse social support scores in the second tertile of cognitive decline (p = 0.008). CONCLUSION: MCI and cognitive decline from premorbid baseline are associated with reduced HR-QOL in communication, stigma, and social support domains. The cognitive decline from premorbid baseline modifies the association between MCI and HR-QOL in PD and knowing both will allow a better appreciation of difficulties patients face in daily life.
Authors: Jacob D Jones; Chris Hass; Paul Mangal; Jacob Lafo; Michael S Okun; Dawn Bowers Journal: Parkinsonism Relat Disord Date: 2014-09-18 Impact factor: 4.891
Authors: Brenna A Cholerton; Cyrus P Zabetian; Jia Y Wan; Thomas J Montine; Joseph F Quinn; Ignacio F Mata; Kathryn A Chung; Amie Peterson; Alberto J Espay; Fredy J Revilla; Johnna Devoto; G Stennis Watson; Shu-Ching Hu; James B Leverenz; Karen L Edwards Journal: Mov Disord Date: 2014-04-07 Impact factor: 10.338
Authors: Achinoam Faust-Socher; Sarah Duff-Canning; Arthur Grabovsky; Melissa J Armstrong; Brandon Rothberg; Paul J Eslinger; Christopher A Meaney; Ruth B Schneider; David F Tang-Wai; Susan H Fox; Cindy Zadikoff; Nancy Kennedy; Kelvin L Chou; Carol Persad; Irene Litvan; Benjamin T Mast; Adam T Gerstenecker; Sandra Weintraub; William Reginold; Connie Marras Journal: Dement Geriatr Cogn Disord Date: 2019-07-17 Impact factor: 2.959
Authors: D Bäckström; M Eriksson Domellöf; G Granåsen; J Linder; S Mayans; E Elgh; H Zetterberg; K Blennow; L Forsgren Journal: Acta Neurol Scand Date: 2017-09-04 Impact factor: 3.209
Authors: Rachael A Lawson; Alison J Yarnall; Gordon W Duncan; Tien K Khoo; David P Breen; Roger A Barker; Daniel Collerton; John-Paul Taylor; David J Burn Journal: Parkinsonism Relat Disord Date: 2014-07-18 Impact factor: 4.891