OBJECTIVES: Some Asian countries have been reluctant to adopt Haemophilus influenzae type b (Hib) conjugate vaccination because of uncertainty over disease burden. We assessed the impact of introduction of Hib conjugate vaccine into the Expanded Program on Immunization in Bangladesh on purulent and laboratory-confirmed H influenzae meningitis. STUDY DESIGN: Within a well-defined catchment area around 2 surveillance hospitals in Dhaka, Bangladesh, we compared the incidence of Hib meningitis confirmed by culture, latex agglutination, and polymerase chain reaction assay among infants 1 year before and 1 year after introduction of Hib conjugate vaccine. We adjusted the incidence rate for the proportion of children who sought care at the surveillance hospitals. RESULTS: Among infants, the incidence of confirmed Hib meningitis decreased from 92-16 cases per 100,000 within 1 year of vaccine introduction (vaccine preventable incidence = 76; 95% CI 18, 135 per 100,000). The incidence of purulent meningitis decreased from 1659-1159 per 100,000 (vaccine preventable incidence = 500; 95% CI: 203, 799 per 100,000). During the same time period, there was no significant difference in the incidence of meningitis due to Streptococcus pneumoniae. CONCLUSIONS: Introduction of conjugate Hib conjugate vaccine into Bangladesh Expanded Program on Immunization markedly reduced the burden of Hib and purulent meningitis.
OBJECTIVES: Some Asian countries have been reluctant to adopt Haemophilus influenzae type b (Hib) conjugate vaccination because of uncertainty over disease burden. We assessed the impact of introduction of Hib conjugate vaccine into the Expanded Program on Immunization in Bangladesh on purulent and laboratory-confirmed H influenzae meningitis. STUDY DESIGN: Within a well-defined catchment area around 2 surveillance hospitals in Dhaka, Bangladesh, we compared the incidence of Hib meningitis confirmed by culture, latex agglutination, and polymerase chain reaction assay among infants 1 year before and 1 year after introduction of Hib conjugate vaccine. We adjusted the incidence rate for the proportion of children who sought care at the surveillance hospitals. RESULTS: Among infants, the incidence of confirmed Hib meningitis decreased from 92-16 cases per 100,000 within 1 year of vaccine introduction (vaccine preventable incidence = 76; 95% CI 18, 135 per 100,000). The incidence of purulent meningitis decreased from 1659-1159 per 100,000 (vaccine preventable incidence = 500; 95% CI: 203, 799 per 100,000). During the same time period, there was no significant difference in the incidence of meningitis due to Streptococcus pneumoniae. CONCLUSIONS: Introduction of conjugate Hib conjugate vaccine into Bangladesh Expanded Program on Immunization markedly reduced the burden of Hib and purulent meningitis.
Authors: Senjuti Saha; Mathuram Santosham; Manzoor Hussain; Robert E Black; Samir K Saha Journal: Am J Trop Med Hyg Date: 2017-11-30 Impact factor: 2.345
Authors: Shampa Saha; Md Hasan; Lindsay Kim; Jennifer L Farrar; Belal Hossain; Maksuda Islam; Asm Nawshad Uddin Ahmed; M Ruhul Amin; Mohammed Hanif; Manzoor Hussain; Shams El-Arifeen; Cynthia G Whitney; Samir K Saha Journal: BMC Public Health Date: 2016-12-07 Impact factor: 3.295
Authors: W Abdullah Brooks; Khalequ Zaman; Doli Goswami; Christine Prosperi; Hubert P Endtz; Lokman Hossain; Mustafizur Rahman; Dilruba Ahmed; Mohammed Ziaur Rahman; Sayera Banu; Arif Uddin Shikder; Yasmin Jahan; Kamrun Nahar; Mohammod Jobayer Chisti; Mohammed Yunus; Muhammad Alfazal Khan; Fariha Bushra Matin; Razib Mazumder; Mohammad Shahriar Bin Elahi; Muhammad Saifullah; Muntasir Alam; Abu Sadat Mohammad Sayeem Bin Shahid; Fahim Haque; Sabiha Sultana; Melissa M Higdon; Meredith Haddix; Daniel R Feikin; David R Murdoch; Laura L Hammitt; Katherine L O'Brien; Maria Deloria Knoll Journal: Pediatr Infect Dis J Date: 2021-09-01 Impact factor: 2.129