Literature DB >> 2377319

Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus.

D D Mott1, D V Lewis, C M Ferrari, W A Wilson, H S Swartzwelder.   

Abstract

The effect of baclofen on the development of long-term potentiation (LTP) in the dentate gyrus was examined. Stimulus trains applied to the perforant path in the presence of baclofen produced significantly more potentiation of the perforant path-evoked response than did similar stimulation in control medium. In addition, baclofen enabled stimulus trains, ordinarily subthreshold for LTP induction, to produce LTP. These results demonstrate that GABAB receptor activation by baclofen makes repetitive stimulation more effective at producing LTP.

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Year:  1990        PMID： 2377319     DOI： 10.1016/0304-3940(90)90307-u

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  6 in total

1.  A meta-analysis of the effects of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation.

Authors:  Apoorva Bhandari; Natasha Radhu; Faranak Farzan; Benoit H Mulsant; Tarek K Rajji; Zafiris J Daskalakis; Daniel M Blumberger
Journal:  Clin Neurophysiol       Date:  2016-06-08       Impact factor: 3.708

2.  Kappa opioid receptors regulate stress-induced cocaine seeking and synaptic plasticity.

Authors:  Nicholas M Graziane; Abigail M Polter; Lisa A Briand; R Christopher Pierce; Julie A Kauer
Journal:  Neuron       Date:  2013-03-06       Impact factor: 17.173

3.  GABAergic inhibition gates excitatory LTP in perirhinal cortex.

Authors:  Vibhakar C Kotak; Ana Mirallave; Todd M Mowery; Dan H Sanes
Journal:  Hippocampus       Date:  2017-09-26       Impact factor: 3.899

4.  Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure.

Authors:  Patrick J Mulholland; Tara L Teppen; Kelsey M Miller; Hannah G Sexton; Subhash C Pandey; H Scott Swartzwelder
Journal:  Alcohol Clin Exp Res       Date:  2018-02-15       Impact factor: 3.455

5.  Suppression of LTP-like plasticity in human motor cortex by the GABAB receptor agonist baclofen.

Authors:  Michelle N McDonnell; Yuri Orekhov; Ulf Ziemann
Journal:  Exp Brain Res       Date:  2007-03-10       Impact factor: 2.064

6.  Compartmental distribution of GABAB receptor-mediated currents along the somatodendritic axis of hippocampal principal cells.

Authors:  Claudius E Degro; Akos Kulik; Sam A Booker; Imre Vida
Journal:  Front Synaptic Neurosci       Date:  2015-03-23
  6 in total

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