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Literature DB >> 23770714

Expression of lymphocyte-derived growth hormone (GH) and GH-releasing hormone receptors in aging rats.

Abstract

In the present study, we show that higher levels of lymphocyte GH are expressed in spleen cells from aging animals compared to young animals. Further, leukocytes from primary and secondary immune tissues and splenic T and B cells from aging rats all express higher levels of GHRH receptors compared to younger animals. Bone marrow and splenic T cells express the highest levels of GHRH receptor in aging animals. Spleen cells from aging animals showed no significant change in proliferation or GH induction after treatment with GHRH. Taken together, the data for the first time show alterations in GH synthesis and expression of the GHRH receptor on cells of the immune system that may play a role in the immune response in aging.

Entities: Chemical Disease Gene Species

Keywords: Aging; GHRH receptors; Growth hormone; Lymphocytes

Mesh：

Substances：

Year: 2013 PMID： 23770714 PMCID： PMC3736351 DOI： 10.1016/j.cellimm.2013.04.009

Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868

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