| Literature DB >> 23769985 |
Ping Liu1, Meiyan Qi, Chengbin Ma, Guoying Lao, Yu Liu, Yan Liu, Yingzi Liu.
Abstract
MicroRNAs negatively regulate target gene expression at the post-transcriptional level during carcinogenesis. Recent advances revealed that the expression levels of several miRNAs are up- or down-regulated in endometrial carcinoma (EC). Here we identify dysregulated miRNAs in EC and we elucidate the essential role of let-7a. The expression of 86 miRNAs in EC was found to be different from adjacent normal endometrial tissues. Moreover, miR-let-7 members are down-regulated in EC and let-7 miRNAs are highly associated with endometrial cancer. A functional investigation revealed that let-7a suppressed proliferation of HeLa cells by targeting Aurora-B. Let-7a also antagonizes Aurora-B functions in promoting carcinoma cell proliferation by down-regulating Aurora-B protein level. Let-7a could be applied for gene therapy against endometrial carcinogenesis.Entities:
Keywords: Endometrial carcinoma cell; Let-7a; MicroRNA; Targeting Aurora-B
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Year: 2013 PMID： 23769985 DOI： 10.1016/j.febslet.2013.05.065
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124