| Literature DB >> 23768930 |
Jessica K Altman1, Alfred Rademaker, Elizabeth Cull, Bing Bing Weitner, Yishai Ofran, Todd L Rosenblat, Augustin Haidau, Jae H Park, Sharona Lee Ram, James M Orsini, Sonia Sandhu, Rosalind Catchatourian, Steven M Trifilio, Nelly G Adel, Olga Frankfurt, Eytan M Stein, George Mallios, Tony Deblasio, Joseph G Jurcic, Stephen Nimer, Loann C Peterson, Hau C Kwaan, Jacob M Rowe, Dan Douer, Martin S Tallman.
Abstract
We hypothesized that the high early death rate (EDR) due to bleeding in acute promyelocytic leukemia (APL) is in part attributable to delays in all- trans retinoic acid (ATRA). We conducted a retrospective analysis of the timing of ATRA administration. 204 consecutive patients with newly diagnosed APL between 1992 and 2009 were identified. The EDR was 11%. 44% of early deaths occurred in the first week. Hemorrhage accounted for 61% of early deaths. ATRA was ordered the day APL was suspected in 31% of patients. Delays in ATRA administration led to increases in the percentage of early deaths from hemorrhage.Entities:
Keywords: ATRA; Acute Promyelocytic Leukemia; Early Death Rate; Hemorrhage
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Year: 2013 PMID： 23768930 DOI： 10.1016/j.leukres.2013.05.007
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156