OBJECTIVE: To evaluate the usefulness of serum and CSF adenosine deaminase (ADA) activity for the diagnosis of tuberculous meningitis (TBM) from other meningitis. METHODS: We studied CSF and serum ADA activity for 83 cases of TBM, 148 of bacterial meningitis (BM), and 262 of viral or aseptic meningitis. RESULTS: The mean ADA activities (IU/L) in CSF and serum were higher in TBM (11.80 ± 2.50, 30.28 ± 7.30) than in other types of meningitis (8.52 ± 3.60, 17.90 ± 9.20 in BM; 5.26 ± 1.90, 8.56 ± 5.9 in viral or aseptic meningitis). When we accepted a serum ADA activity cut-off value of 15 IU/L for the differential diagnosis of TBM and non-TBM with ROC analysis, the sensitivity was 84% and specificity was 82%. Combining CSF (≥ 10) and serum (≥ 15) ADA activity significantly increased overall specificity from 92% to 97% for the diagnosis of TBM. CONCLUSIONS: The determination of CSF and serum ADA activity is a simple and reliable test for differentiating TBM from other types of meningitis.
OBJECTIVE: To evaluate the usefulness of serum and CSF adenosine deaminase (ADA) activity for the diagnosis of tuberculous meningitis (TBM) from other meningitis. METHODS: We studied CSF and serum ADA activity for 83 cases of TBM, 148 of bacterial meningitis (BM), and 262 of viral or aseptic meningitis. RESULTS: The mean ADA activities (IU/L) in CSF and serum were higher in TBM (11.80 ± 2.50, 30.28 ± 7.30) than in other types of meningitis (8.52 ± 3.60, 17.90 ± 9.20 in BM; 5.26 ± 1.90, 8.56 ± 5.9 in viral or aseptic meningitis). When we accepted a serum ADA activity cut-off value of 15 IU/L for the differential diagnosis of TBM and non-TBM with ROC analysis, the sensitivity was 84% and specificity was 82%. Combining CSF (≥ 10) and serum (≥ 15) ADA activity significantly increased overall specificity from 92% to 97% for the diagnosis of TBM. CONCLUSIONS: The determination of CSF and serum ADA activity is a simple and reliable test for differentiating TBM from other types of meningitis.
Authors: Jorge Parra-Ruiz; V Ramos; C Dueñas; N M Coronado-Álvarez; R Cabo-Magadán; V Portillo-Tuñón; D Vinuesa; L Muñoz-Medina; J Hernández-Quero Journal: Infection Date: 2015-04-14 Impact factor: 3.553
Authors: L R Costa; A K Y de Souza; J N Scholl; F Figueiró; A M O Battastini; J A Dos Santos Jaques; F F Zanoelo Journal: Braz J Med Biol Res Date: 2021-05-24 Impact factor: 2.590
Authors: Young Seob Jeong; Minjun Jeon; Joung Ha Park; Min Chul Kim; Eunyoung Lee; Se Yoon Park; Yu Mi Lee; Sungim Choi; Seong Yeon Park; Ki Ho Park; Sung Han Kim; Min Huok Jeon; Eun Ju Choo; Tae Hyong Kim; Mi Suk Lee; Tark Kim Journal: Infect Chemother Date: 2020-12-11