Elizabeth Crocco1, Rosie E Curiel1, Amarilis Acevedo2, Sara J Czaja1, David A Loewenstein3. 1. Center on Aging and Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL. 2. Department of Psychology, Nova Southeastern University, Davie, FL. 3. Center on Aging and Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami, FL. Electronic address: dloewenstein@med.miami.edu.
Abstract
OBJECTIVES: To determine the degree to which susceptibility to different types of semantic interference may reflect the initial manifestations of early Alzheimer's disease (AD) beyond the effects of global memory impairment. METHODS: Normal elderly (NE) subjects (n = 47), subjects with amnestic mild cognitive impairment (aMCI; n = 34), and subjects with probable AD (n = 40) were evaluated by using a unique cued recall paradigm that allowed for evaluation of both proactive and retroactive interference effects while controlling for global memory impairment (i.e., Loewenstein-Acevedo Scales of Semantic Interference and Learning [LASSI-L] procedure). RESULTS: Controlling for overall memory impairment, aMCI subjects had much greater proactive and retroactive interference effects than NE subjects. LASSI-L indices of learning by using cued recall revealed high levels of sensitivity and specificity, with an overall correct classification rate of 90%. These measures provided better discrimination than traditional neuropsychological measures of memory function. CONCLUSIONS: The LASSI-L paradigm is unique and unlike other assessments of memory in that items posed for cued recall are explicitly presented, and semantic interference and cueing effects can be assessed while controlling for initial level of memory impairment. This is a powerful procedure that allows the participant to serve as his or her own control. The high levels of discrimination between subjects with aMCI and normal cognition that exceeded traditional neuropsychological measures makes the LASSI-L worthy of further research in the detection of early AD.
OBJECTIVES: To determine the degree to which susceptibility to different types of semantic interference may reflect the initial manifestations of early Alzheimer's disease (AD) beyond the effects of global memory impairment. METHODS: Normal elderly (NE) subjects (n = 47), subjects with amnestic mild cognitive impairment (aMCI; n = 34), and subjects with probable AD (n = 40) were evaluated by using a unique cued recall paradigm that allowed for evaluation of both proactive and retroactive interference effects while controlling for global memory impairment (i.e., Loewenstein-Acevedo Scales of Semantic Interference and Learning [LASSI-L] procedure). RESULTS: Controlling for overall memory impairment, aMCI subjects had much greater proactive and retroactive interference effects than NE subjects. LASSI-L indices of learning by using cued recall revealed high levels of sensitivity and specificity, with an overall correct classification rate of 90%. These measures provided better discrimination than traditional neuropsychological measures of memory function. CONCLUSIONS: The LASSI-L paradigm is unique and unlike other assessments of memory in that items posed for cued recall are explicitly presented, and semantic interference and cueing effects can be assessed while controlling for initial level of memory impairment. This is a powerful procedure that allows the participant to serve as his or her own control. The high levels of discrimination between subjects with aMCI and normal cognition that exceeded traditional neuropsychological measures makes the LASSI-L worthy of further research in the detection of early AD.
Authors: David A Loewenstein; Amarilis Acevedo; Lynn Schram; Raymond Ownby; Gloria White; Brian Mogosky; William W Barker; Ranjan Duara Journal: Am J Geriatr Psychiatry Date: 2003 Mar-Apr Impact factor: 4.105
Authors: David A Loewenstein; Rosie E Curiel; Maria T Greig; Russell M Bauer; Marian Rosado; Dawn Bowers; Meredith Wicklund; Elizabeth Crocco; Michael Pontecorvo; Abhinay D Joshi; Rosemarie Rodriguez; Warren W Barker; Jacqueline Hidalgo; Ranjan Duara Journal: Am J Geriatr Psychiatry Date: 2016-04-04 Impact factor: 4.105
Authors: Gali H Weissberger; Jessica V Strong; Kayla B Stefanidis; Mathew J Summers; Mark W Bondi; Nikki H Stricker Journal: Neuropsychol Rev Date: 2017-09-22 Impact factor: 7.444
Authors: Kelsey R Thomas; Joel Eppig; Emily C Edmonds; Diane M Jacobs; David J Libon; Rhoda Au; David P Salmon; Mark W Bondi Journal: Neuropsychology Date: 2018-02 Impact factor: 3.295
Authors: Elizabeth A Crocco; David A Loewenstein; Rosie E Curiel; Noam Alperin; Sara J Czaja; Philip D Harvey; Xiaoyan Sun; Joshua Lenchus; Arlene Raffo; Ailyn Peñate; Jose Melo; Lee Sang; Rosemery Valdivia; Karen Cardenas Journal: J Psychiatr Res Date: 2017-08-24 Impact factor: 4.791
Authors: David A Loewenstein; Rosie E Curiel; Steven DeKosky; Russell M Bauer; Monica Rosselli; Salvador M Guinjoan; Malek Adjouadi; Ailyn Peñate; William W Barker; Sindy Goenaga; Todd Golde; Maria T Greig-Custo; Kevin S Hanson; Chunfei Li; Gabriel Lizarraga; Michael Marsiske; Ranjan Duara Journal: Neurology Date: 2018-08-03 Impact factor: 9.910
Authors: Rosie E Curiel; Elizabeth Crocco; Marian Rosado; Ranjan Duara; Maria T Greig; Arlene Raffo; David A Loewenstein Journal: J Alzheimers Dis Date: 2016-09-06 Impact factor: 4.472