OBJECTIVES: Genital human papillomavirus (HPV) infections and associated precancerous lesions adversely affect health-related quality of life (HRQoL). HPV vaccines provide effective protection against these conditions. We therefore investigated the impact of HPV vaccination on HRQoL in young women five years after participation in a phase III HPV vaccination trial. METHODS: A total of 4808 originally 16- to 17-year-old Finnish girls had participated in the PATRICIA trial and received either bivalent HPV 16/18 vaccine or hepatitis A-virus (HAV) vaccine in 2004 to 2005. Unvaccinated girls (n = 9602), from adjacent birth cohorts, had participated in the control cohort in 2005. From 2009 to 2011, at 22 to 23 years of age, all participants received a questionnaire consisting of two generic HRQoL instruments (RAND36 and EQ VAS) and a disease-specific questionnaire (CECA10). RESULTS: We analysed responses of 1143 HPV 16/18-vaccinated, 980 HAV-vaccinated, and 3753 unvaccinated young women. The unadjusted mean outcome measures of the different HRQoL estimates were similar in the three different responder cohorts. CONCLUSIONS: Five years after vaccination the health-related quality of life of HPV 16/ 18- vaccinated young women did not differ from those of HAV-vaccinated or unvaccinated controls representing the general population.
OBJECTIVES: Genital human papillomavirus (HPV) infections and associated precancerous lesions adversely affect health-related quality of life (HRQoL). HPV vaccines provide effective protection against these conditions. We therefore investigated the impact of HPV vaccination on HRQoL in young women five years after participation in a phase III HPV vaccination trial. METHODS: A total of 4808 originally 16- to 17-year-old Finnish girls had participated in the PATRICIA trial and received either bivalent HPV 16/18 vaccine or hepatitis A-virus (HAV) vaccine in 2004 to 2005. Unvaccinated girls (n = 9602), from adjacent birth cohorts, had participated in the control cohort in 2005. From 2009 to 2011, at 22 to 23 years of age, all participants received a questionnaire consisting of two generic HRQoL instruments (RAND36 and EQ VAS) and a disease-specific questionnaire (CECA10). RESULTS: We analysed responses of 1143 HPV 16/18-vaccinated, 980 HAV-vaccinated, and 3753 unvaccinated young women. The unadjusted mean outcome measures of the different HRQoL estimates were similar in the three different responder cohorts. CONCLUSIONS: Five years after vaccination the health-related quality of life of HPV 16/ 18- vaccinated young women did not differ from those of HAV-vaccinated or unvaccinated controls representing the general population.
Authors: A Ó Céilleachair; J F O'Mahony; M O'Connor; J O'Leary; C Normand; C Martin; L Sharp Journal: Qual Life Res Date: 2017-06-26 Impact factor: 4.147
Authors: Matti Lehtinen; Camilla Lagheden; Tapio Luostarinen; Tiina Eriksson; Dan Apter; Katja Harjula; Marjo Kuortti; Kari Natunen; Johanna Palmroth; Tiina Petäjä; Eero Pukkala; Mari Siitari-Mattila; Frank Struyf; Pekka Nieminen; Jorma Paavonen; Gary Dubin; Joakim Dillner Journal: BMJ Open Date: 2017-08-18 Impact factor: 2.692
Authors: Matti Lehtinen; Camilla Lagheden; Tapio Luostarinen; Tiina Eriksson; Dan Apter; Anne Bly; Penelope Gray; Katja Harjula; Kaisa Heikkilä; Mari Hokkanen; Heidi Karttunen; Marjo Kuortti; Pekka Nieminen; Mervi Nummela; J Paavonen; Johanna Palmroth; Tiina Petäjä; Eero Pukkala; Anna Soderlund-Strand; Ulla Veivo; Joakim Dillner Journal: BMJ Open Date: 2021-12-30 Impact factor: 2.692