Literature DB >> 23766829

Blood transfusion and hemostatic agents used during radical cystectomy.

Nahid Punjani1, Luke T Lavallée, Franco Momoli, Dean Fergusson, Kelsey Witiuk, Ranjeeta Mallick, Christopher Morash, Ilias Cagiannos, Rodney H Breau.   

Abstract

BACKGROUND: Radical cystectomy may result in significant blood loss necessitating transfusion. The purpose of this study was to determine what intra-operative techniques and hemostatic agents are currently used by uro-oncologists to prevent and control blood loss during radical cystectomy.
METHODS: In August 2011, members of the Society of Urologic Oncology (SUO) were solicited to complete an online survey. Residents, fellows and non-urologists were excluded. Canadian members received a personal email invitation. Respondents were asked to provide demographic information and opinions regarding blood loss and transfusion. Participants were also asked to report techniques used to reduce blood loss.
RESULTS: Of the 34 Canadian SUO members with registered email addresses, 27 (79%) completed the survey and met inclusion criteria as staff urologists who perform radical cystectomy. In addition, 52 non-Canadian SUO members were included in the analysis. Among all SUO respondents, a high proportion (73; 88%) reported using topical hemostatic agents during cystectomy. Thirty-six (46%) surgeons reported occasionally using procedural techniques and 9 (11%) using systemic hemostatic agents. Number of years since training was associated with decreased use of topical agents and increased use of procedural techniques (p < 0.01). Number of cystectomies per year was associated with decreased use of topical hemostatic agents (p < 0.01).
INTERPRETATION: Based on a survey of practice, there is significant risk of blood loss requiring transfusion during radical cystectomy. Surgeons frequently use topical hemostatic agents and rarely use systemic drugs to prevent or control blood loss. Trials evaluating agents and techniques to reduce blood loss during radical cystectomy are needed.

Entities:  

Year:  2013        PMID: 23766829      PMCID: PMC3668410          DOI: 10.5489/cuaj.1002

Source DB:  PubMed          Journal:  Can Urol Assoc J        ISSN: 1911-6470            Impact factor:   1.862


  20 in total

Review 1.  Blood use strategies in urologic surgery.

Authors:  W B Gilbert; J A Smith
Journal:  Urology       Date:  2000-04       Impact factor: 2.649

2.  Identifying risk factors for potentially avoidable complications following radical cystectomy.

Authors:  Brent K Hollenbeck; David C Miller; David Taub; Rodney L Dunn; Shukri F Khuri; William G Henderson; James E Montie; Willie Underwood; John T Wei
Journal:  J Urol       Date:  2005-10       Impact factor: 7.450

Review 3.  Appropriateness of allogeneic red blood cell transfusion: the international consensus conference on transfusion outcomes.

Authors:  Aryeh Shander; Arlene Fink; Mazyar Javidroozi; Jochen Erhard; Shannon L Farmer; Howard Corwin; Lawrence Tim Goodnough; Axel Hofmann; James Isbister; Sherri Ozawa; Donat R Spahn
Journal:  Transfus Med Rev       Date:  2011-04-17

4.  Acute normovolemic hemodilution for radical retropubic prostatectomy and radical cystectomy.

Authors:  Akio Takayanagi; Naoya Masumori; Ko Kobayashi; Yasuharu Kunishima; Atsushi Takahashi; Naoki Itoh; Michiaki Yamakage; Masayoshi Namiki; Taiji Tsukamoto
Journal:  Urology       Date:  2008-03-04       Impact factor: 2.649

Review 5.  A comprehensive review of topical hemostatic agents: efficacy and recommendations for use.

Authors:  Hardean E Achneck; Bantayehu Sileshi; Ryan M Jamiolkowski; David M Albala; Mark L Shapiro; Jeffrey H Lawson
Journal:  Ann Surg       Date:  2010-02       Impact factor: 12.969

6.  Acute normovolemic hemodilution for radical prostatectomy: can it replace preoperative autologous blood transfusion?

Authors:  N Terada; Y Arai; Y Matsuta; S Maekawa; K Okubo; K Ogura; N Matsuda; A Yonei
Journal:  Int J Urol       Date:  2001-04       Impact factor: 3.369

7.  Use of acute normovolemic hemodilution in patients undergoing radical prostatectomy.

Authors:  Akito Terai; Naoki Terada; Koji Yoshimura; Kentaro Ichioka; Nobufumi Ueda; Noriaki Utsunomiya; Naoki Kohei; Yoichi Arai; Akitomo Yonei
Journal:  Urology       Date:  2005-06       Impact factor: 2.649

Review 8.  Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion.

Authors:  David A Henry; Paul A Carless; Annette J Moxey; Dianne O'Connell; Barrie J Stokes; Dean A Fergusson; Katharine Ker
Journal:  Cochrane Database Syst Rev       Date:  2011-01-19

9.  Comparative analysis of laparoscopic and robot-assisted radical cystectomy with ileal conduit urinary diversion.

Authors:  Jose Benito A Abraham; Jennifer L Young; Geoffrey N Box; Hak J Lee; Leslie A Deane; David K Ornstein
Journal:  J Endourol       Date:  2007-12       Impact factor: 2.942

10.  The use of cell salvage during radical retropubic prostatectomy: does it influence cancer recurrence?

Authors:  M Davis; M Sofer; O Gomez-Marin; D Bruck; M S Soloway
Journal:  BJU Int       Date:  2003-04       Impact factor: 5.588

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  2 in total

Review 1.  Impact of perioperative blood transfusions on clinical outcomes in patients undergoing surgery for major urologic malignancies.

Authors:  Yasmin Abu-Ghanem; Jacob Ramon
Journal:  Ther Adv Urol       Date:  2019-08-12

2.  Tranexamic Acid versus Placebo to Prevent Blood Transfusion during Radical Cystectomy for Bladder Cancer (TACT): Study Protocol for a Randomized Controlled Trial.

Authors:  Rodney H Breau; Luke T Lavallée; Sonya Cnossen; Kelsey Witiuk; Ilias Cagiannos; Franco Momoli; Gregory Bryson; Salmaan Kanji; Christopher Morash; Alexis Turgeon; Ryan Zarychanski; Ranjeeta Mallick; Greg Knoll; Dean A Fergusson
Journal:  Trials       Date:  2018-05-02       Impact factor: 2.279

  2 in total

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