Valerie A Fritsch1, Eric J Lentsch. 1. Department of Otolaryngology - Head and Neck Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Abstract
BACKGROUND: Basaloid squamous cell carcinoma (BSCC) is a rare subtype squamous cell carcinoma (SCC) that frequently occurs in the larynx. BSCC is generally considered an aggressive SCC variant; however, because of its rarity, most studies are underpowered to detect statistical differences in disease-specific survival (DSS). METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) database, we compared clinicopathologic data and DSS between patients with laryngeal BSCC and SCC. RESULTS: Patients with relative SCC, those with laryngeal BSCC, presented with more advanced local, regional, and distant disease (p < .001). Patients with BSCC had worse DSS, regardless of stage, tumor location within the larynx (glottis/supraglottis; p < .001), or treatment received (p ≤ .052). CONCLUSION: Analysis of the largest laryngeal BSCC series to date (n = 145) demonstrates that BSCC carries a worse prognosis than conventional SCC of the larynx.
BACKGROUND:Basaloid squamous cell carcinoma (BSCC) is a rare subtype squamous cell carcinoma (SCC) that frequently occurs in the larynx. BSCC is generally considered an aggressive SCC variant; however, because of its rarity, most studies are underpowered to detect statistical differences in disease-specific survival (DSS). METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) database, we compared clinicopathologic data and DSS between patients with laryngeal BSCC and SCC. RESULTS:Patients with relative SCC, those with laryngeal BSCC, presented with more advanced local, regional, and distant disease (p < .001). Patients with BSCC had worse DSS, regardless of stage, tumor location within the larynx (glottis/supraglottis; p < .001), or treatment received (p ≤ .052). CONCLUSION: Analysis of the largest laryngeal BSCC series to date (n = 145) demonstrates that BSCC carries a worse prognosis than conventional SCC of the larynx.
Authors: Fernando López; Michelle D Williams; Antonio Cardesa; Jennifer L Hunt; Primož Strojan; Alessandra Rinaldo; Iain J Nixon; Juan P Rodrigo; Nabil F Saba; William M Mendenhall; Miquel Quer; Carlos Suárez; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2017-03-31 Impact factor: 2.503
Authors: A Osman; M S Ciolofan; E Ioniță; I Ioniță; F Anghelina; C A Mogoantă; A S Enescu; A Enescu; M Toader Journal: Curr Health Sci J Date: 2015-12-22