BACKGROUND: The cost-effectiveness of the frozen section for assessment of margin in head and neck squamous cell carcinoma (HNSCC) is still contentious. The purpose of this study was to evaluate whether gross examination of margin is an alternative to frozen section. METHODS: It was a prospective observational study in 145 consecutive patients undergoing surgery for HNSCC. Surgical margins were first assessed by the surgeons with a metallic scale. All specimens were then examined using frozen section and permanent section. RESULTS: Overall, 83% of inadequate margins were detected by frozen section. The chances of inadequate margin were very low if gross surgical margin were 7 mm or more. Gross examination alone (with 7 mm as cutoff) predicted 88% of the inadequate surgical margin. There was no difference in precision of frozen section vis-à-vis gross examination with 7 mm cut off (p ≤ .8). CONCLUSION: Achievement of 7 mm surgical margin measured by a surgeon obviates the need for frozen section.
BACKGROUND: The cost-effectiveness of the frozen section for assessment of margin in head and neck squamous cell carcinoma (HNSCC) is still contentious. The purpose of this study was to evaluate whether gross examination of margin is an alternative to frozen section. METHODS: It was a prospective observational study in 145 consecutive patients undergoing surgery for HNSCC. Surgical margins were first assessed by the surgeons with a metallic scale. All specimens were then examined using frozen section and permanent section. RESULTS: Overall, 83% of inadequate margins were detected by frozen section. The chances of inadequate margin were very low if gross surgical margin were 7 mm or more. Gross examination alone (with 7 mm as cutoff) predicted 88% of the inadequate surgical margin. There was no difference in precision of frozen section vis-à-vis gross examination with 7 mm cut off (p ≤ .8). CONCLUSION: Achievement of 7 mm surgical margin measured by a surgeon obviates the need for frozen section.
Authors: Mark W Kubik; Shaum Sridharan; Mark A Varvares; Dan P Zandberg; Heath D Skinner; Raja R Seethala; Simion I Chiosea Journal: Head Neck Pathol Date: 2020-03-02
Authors: Elisa M Barroso; Yassine Aaboubout; Lisette C van der Sar; Hetty Mast; Aniel Sewnaik; Jose A Hardillo; Ivo Ten Hove; Maria R Nunes Soares; Lars Ottevanger; Tom C Bakker Schut; Gerwin J Puppels; Senada Koljenović Journal: Front Oncol Date: 2021-03-30 Impact factor: 6.244
Authors: Vidisha Tuljapurkar; Harsh Dhar; Aseem Mishra; Swagnik Chakraborti; Pankaj Chaturvedi; Prathamesh S Pai Journal: South Asian J Cancer Date: 2016 Jul-Sep
Authors: Caterina Giannitto; Giuseppe Mercante; Luca Disconzi; Riccardo Boroni; Elena Casiraghi; Federica Canzano; Michele Cerasuolo; Francesca Gaino; Armando De Virgilio; Barbara Fiamengo; Fabio Ferreli; Andrea Alessandro Esposito; Paolo Oliva; Flavio Ronzoni; Luigi Terracciano; Giuseppe Spriano; Luca Balzarini Journal: Front Oncol Date: 2021-12-09 Impact factor: 6.244