Directed studies towards the total synthesis of (+)-13-deoxytedanolide: simple and convenient synthesis of the C8-C16 fragment.

A straightforward synthesis of the enantioenriched C8-C16 south part of (+)-13-deoxytedanolide has been reported. The strength of this approach relies on the preparation of similar functionalized fragments via the transformation of a unique dihydrofuran building block through a 1,2-metallate rearrangement.