Literature DB >> 23764838

Amyloidogenic peptide homologous to fragment 129-148 of human myocilin.

Vladimir V Egorov1, Natalia A Grudinina, Dmitry V Lebedev, Aram A Shaldzhyan, Alexander V Slita, Alexey K Sirotkin, Andrey V Vasin, Michael M Shavlovsky.   

Abstract

Myocilin is a protein with a molecular weight near 50 kDa. It is expressed in almost all organs and tissues. We showed that the peptide DQLETQTRELETAYSNLLRD corresponding to N-terminal Leucine zipper motif (LZM) of the protein is able to form amyloid-like fibrils. The possible role of this motif in myocilin aggregation is discussed.

Entities:  

Keywords:  fibrillogenesis; leucine zipper motif; myocilin

Mesh：

Substances：

Year:  2013        PMID： 23764838      PMCID： PMC3783111          DOI： 10.4161/pri.24239

Source DB:  PubMed          Journal:  Prion        ISSN： 1933-6896            Impact factor:   3.931


  8 in total

1.  A designed system for assessing how sequence affects alpha to beta conformational transitions in proteins.

Authors:  Barbara Ciani; E Gail Hutchinson; Richard B Sessions; Derek N Woolfson
Journal:  J Biol Chem       Date:  2001-12-21       Impact factor: 5.157

2.  Myocilin is associated with mitochondria in human trabecular meshwork cells.

Authors:  Kelly Wentz-Hunter; Jun Ueda; Nibuyoshi Shimizu; Beatrice Y J T Yue
Journal:  J Cell Physiol       Date:  2002-01       Impact factor: 6.384

3.  The stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder.

Authors:  J Nicole Burns; Katherine C Turnage; Chandler A Walker; Raquel L Lieberman
Journal:  Biochemistry       Date:  2011-06-09       Impact factor: 3.162

4.  Amyloid fibril formation by the glaucoma-associated olfactomedin domain of myocilin.

Authors:  Susan D Orwig; Christopher W Perry; Laura Y Kim; Katherine C Turnage; Rong Zhang; Douglas Vollrath; Ingeborg Schmidt-Krey; Raquel L Lieberman
Journal:  J Mol Biol       Date:  2011-12-13       Impact factor: 5.469

5.  Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells.

Authors:  T D Nguyen; P Chen; W D Huang; H Chen; D Johnson; J R Polansky
Journal:  J Biol Chem       Date:  1998-03-13       Impact factor: 5.157

6.  Protein interactions with myocilin.

Authors:  Kelly Wentz-Hunter; Jun Ueda; Beatrice Y J T Yue
Journal:  Invest Ophthalmol Vis Sci       Date:  2002-01       Impact factor: 4.799

7.  Evaluation and understanding of myocilin mutations in Indian primary open angle glaucoma patients.

Authors:  Janakaraj Kanagavalli; Subbaiah Ramasamy Krishnadas; Eswari Pandaranayaka; Sankaran Krishnaswamy; Periasamy Sundaresan
Journal:  Mol Vis       Date:  2003-11-14       Impact factor: 2.367

8.  Heterozygous expression of myocilin glaucoma mutants increases secretion of the mutant forms and reduces extracellular processed myocilin.

Authors:  José-Daniel Aroca-Aguilar; Francisco Sánchez-Sánchez; Francisco Martínez-Redondo; Miguel Coca-Prados; Julio Escribano
Journal:  Mol Vis       Date:  2008-11-21       Impact factor: 2.367
  8 in total
  2 in total

1.  A conservative mutant of a proteolytic fragment produced during fibril formation enhances fibrillogenesis.

Authors:  Vladimir V Egorov; Dmitry V Lebedev; Aram A Shaldzhyan; Alexey K Sirotkin; Andrey N Gorshkov; Olga A Mirgorodskaya; Natalia A Grudinina; Andrey V Vasin; Michael M Shavlovsky
Journal:  Prion       Date:  2014       Impact factor: 3.931

Review 2.  Peptide-Induced Amyloid-Like Conformational Transitions in Proteins.

Authors:  Vladimir Egorov; Natalia Grudinina; Andrey Vasin; Dmitry Lebedev
Journal:  Int J Pept       Date:  2015-09-08
  2 in total

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