Literature DB >> 23763998

Mind the IQGAP.

Berta Sanchez-Laorden1, Amaya Viros, Richard Marais.   

Abstract

The scaffold protein IQGAP1 regulates cell signaling through the RAF/MEK/ERK pathway. Recent data show that cancer cells in which the RAF/MEK/ERK pathway is activated are particularly sensitive to the disruption of IQGAP1 function. IQGAP drugs may be particularly effective in tumors that develop resistance to existing pathway drugs.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23763998     DOI： 10.1016/j.ccr.2013.05.017

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  12 in total

1.  The Ras GTPase-activating-like protein IQGAP1 is downregulated in human diabetic nephropathy and associated with ERK1/2 pathway activation.

Authors:  Hua Zhou; Chunlei Yao; Ao Bian; Jun Qian; Xiufen Zhao; Yanting Zhao; Weiwei Wang; Changying Xing
Journal:  Mol Cell Biochem       Date:  2014-02-02       Impact factor: 3.396

2.  In Silico Analysis Validates Proteomic Findings of Formalin-fixed Paraffin Embedded Cutaneous Squamous Cell Carcinoma Tissue.

Authors:  Ali Azimi; Kimberley L Kaufman; Marina Ali; Steven Kossard; Pablo Fernandez-Penas
Journal:  Cancer Genomics Proteomics       Date:  2016 11-12       Impact factor: 4.069

3.  The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2.

Authors:  A Jane Bardwell; Leonila Lagunes; Ronak Zebarjedi; Lee Bardwell
Journal:  J Biol Chem       Date:  2017-04-10       Impact factor: 5.157

4.  Comprehensive characterization of glioblastoma tumor tissues for biomarker identification using mass spectrometry-based label-free quantitative proteomics.

Authors:  Maxime S Heroux; Marla A Chesnik; Brian D Halligan; Mona Al-Gizawiy; Jennifer M Connelly; Wade M Mueller; Scott D Rand; Elizabeth J Cochran; Peter S LaViolette; Mark G Malkin; Kathleen M Schmainda; Shama P Mirza
Journal:  Physiol Genomics       Date:  2014-05-06       Impact factor: 3.107

Review 5.  PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective.

Authors:  Mingzhen Zhang; Hyunbum Jang; Ruth Nussinov
Journal:  Cancer Res       Date:  2020-10-12       Impact factor: 13.312

6.  Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer.

Authors:  Balázs Győrffy; Iwona Stelniec-Klotz; Christian Sigler; Katharina Kasack; Torben Redmer; Yu Qian; Reinhold Schäfer
Journal:  Oncotarget       Date:  2015-05-30

7.  Differential transcriptome profile of peripheral white cells to identify biomarkers involved in oxaliplatin induced neuropathy.

Authors:  Manuel Morales; Julio Ávila; Rebeca González-Fernández; Laia Boronat; María Luisa Soriano; Pablo Martín-Vasallo
Journal:  J Pers Med       Date:  2014-06-05

8.  Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy.

Authors:  Deborah Rotoli; Manuel Morales; Julio Ávila; María Del Carmen Maeso; María Del Pino García; Ali Mobasheri; Pablo Martín-Vasallo
Journal:  Int J Mol Sci       Date:  2017-04-22       Impact factor: 5.923

Review 9.  An emerging role for IQGAP1 in tight junction control.

Authors:  Barbara E Tanos; Charles Yeaman; Enrique Rodriguez-Boulan
Journal:  Small GTPases       Date:  2016-11-23

10.  Ras GTPase-Activating-Like Protein IQGAP1 (IQGAP1) Promotes Breast Cancer Proliferation and Invasion and Correlates with Poor Clinical Outcomes.

Authors:  Fanye Zeng; Weihua Jiang; Wei Zhao; Yuxiang Fan; Yanhua Zhu; Hongliang Zhang
Journal:  Med Sci Monit       Date:  2018-05-20
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