Literature DB >> 23763996

Cancer Stem Cells Activate STAT3 the EZ Way.

Shaun D Fouse1, Joseph F Costello.   

Abstract

Activated STAT3 and increased expression of the histone methyltransferase EZH2 are independently associated with the most malignant subset of gliomas. In this issue of Cancer Cell, Kim and colleagues discover that EZH2 enhances STAT3 activation by trimethylating lysine180 in STAT3 and does so preferentially in glioma stem-like cells.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23763996      PMCID： PMC3706087          DOI： 10.1016/j.ccr.2013.05.016

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

1.  PRC2 directly methylates GATA4 and represses its transcriptional activity.

Authors:  Aibin He; Xiaohua Shen; Qing Ma; Jingjing Cao; Alexander von Gise; Pingzhu Zhou; Gang Wang; Victor E Marquez; Stuart H Orkin; William T Pu
Journal:  Genes Dev       Date:  2012-01-01       Impact factor: 11.361

2.  Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.

Authors:  Jinbo Yang; Jing Huang; Maupali Dasgupta; Nathan Sears; Masaru Miyagi; Benlian Wang; Mark R Chance; Xing Chen; Yuping Du; Yuxin Wang; Lizhe An; Qin Wang; Tao Lu; Xiaodong Zhang; Zhenghe Wang; George R Stark
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-23       Impact factor: 11.205

3.  Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

Authors:  Damian B Yap; Justin Chu; Tobias Berg; Matthieu Schapira; S-W Grace Cheng; Annie Moradian; Ryan D Morin; Andrew J Mungall; Barbara Meissner; Merrill Boyle; Victor E Marquez; Marco A Marra; Randy D Gascoyne; R Keith Humphries; Cheryl H Arrowsmith; Gregg B Morin; Samuel A J R Aparicio
Journal:  Blood       Date:  2010-12-29       Impact factor: 22.113

4.  EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent.

Authors:  Kexin Xu; Zhenhua Jeremy Wu; Anna C Groner; Housheng Hansen He; Changmeng Cai; Rosina T Lis; Xiaoqiu Wu; Edward C Stack; Massimo Loda; Tao Liu; Han Xu; Laura Cato; James E Thornton; Richard I Gregory; Colm Morrissey; Robert L Vessella; Rodolfo Montironi; Cristina Magi-Galluzzi; Philip W Kantoff; Steven P Balk; X Shirley Liu; Myles Brown
Journal:  Science       Date:  2012-12-14       Impact factor: 47.728

5.  Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.

Authors:  Tai-Lung Cha; Binhua P Zhou; Weiya Xia; Yadi Wu; Cheng-Chieh Yang; Chun-Te Chen; Bo Ping; Arie P Otte; Mien-Chie Hung
Journal:  Science       Date:  2005-10-14       Impact factor: 47.728

6.  Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.

Authors:  Peter W Lewis; Manuel M Müller; Matthew S Koletsky; Francisco Cordero; Shu Lin; Laura A Banaszynski; Benjamin A Garcia; Tom W Muir; Oren J Becher; C David Allis
Journal:  Science       Date:  2013-03-28       Impact factor: 47.728

7.  EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex.

Authors:  Ji Min Lee; Jason S Lee; Hyunkyung Kim; Kyeongkyu Kim; Hyejin Park; Ji-Young Kim; Seung Hoon Lee; Ik Soo Kim; Joomyung Kim; Minkyoung Lee; Chin Ha Chung; Sang-Beom Seo; Jong-Bok Yoon; Eunyoung Ko; Dong-Young Noh; Keun Il Kim; Kyeong Kyu Kim; Sung Hee Baek
Journal:  Mol Cell       Date:  2012-10-11       Impact factor: 17.970

8.  The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.

Authors:  Kui-Ming Chan; Dong Fang; Haiyun Gan; Rintaro Hashizume; Chuanhe Yu; Mark Schroeder; Nalin Gupta; Sabine Mueller; C David James; Robert Jenkins; Jann Sarkaria; Zhiguo Zhang
Journal:  Genes Dev       Date:  2013-04-19       Impact factor: 11.361

9.  The transcriptional network for mesenchymal transformation of brain tumours.

Authors:  Maria Stella Carro; Wei Keat Lim; Mariano Javier Alvarez; Robert J Bollo; Xudong Zhao; Evan Y Snyder; Erik P Sulman; Sandrine L Anne; Fiona Doetsch; Howard Colman; Anna Lasorella; Ken Aldape; Andrea Califano; Antonio Iavarone
Journal:  Nature       Date:  2009-12-23       Impact factor: 49.962
  9 in total
  12 in total

1.  Enhancer of Zeste Homolog 2 (EZH2) Is a Marker of High-Grade Neuroendocrine Neoplasia in Gastroenteropancreatic and Pulmonary Tract and Predicts Poor Prognosis.

Authors:  Sebastian C B Bremer; Gabi Bittner; Omar Elakad; Helen Dinter; Jochen Gaedcke; Alexander O König; Ahmad Amanzada; Volker Ellenrieder; Alexander Freiherr von Hammerstein-Equord; Philipp Ströbel; Hanibal Bohnenberger
Journal:  Cancers (Basel)       Date:  2022-06-08       Impact factor: 6.575

Review 2.  Molecular targets of isothiocyanates in cancer: recent advances.

Authors:  Parul Gupta; Bonglee Kim; Sung-Hoon Kim; Sanjay K Srivastava
Journal:  Mol Nutr Food Res       Date:  2014-02-10       Impact factor: 5.914

3.  ICAM3 mediates inflammatory signaling to promote cancer cell stemness.

Authors:  Wenzhi Shen; Junling Xie; Shuangtao Zhao; Renle Du; Xiaohe Luo; Huiwen He; Shan Jiang; Na Hao; Chong Chen; Chunlei Guo; Yanhua Liu; Yanan Chen; Peiqing Sun; Shengyong Yang; Na Luo; Rong Xiang; Yunping Luo
Journal:  Cancer Lett       Date:  2018-03-02       Impact factor: 8.679

4.  Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.

Authors:  Ravi Thakur; Rachana Trivedi; Namrata Rastogi; Manisha Singh; Durga Prasad Mishra
Journal:  Sci Rep       Date:  2015-05-14       Impact factor: 4.379

5.  Genetic variants in the EPCAM gene is associated with the prognosis of transarterial chemoembolization treated hepatocellular carcinoma with portal vein tumor thrombus.

Authors:  Xiaohe Yu; Naijian Ge; Xu Guo; Shuqun Shen; Jun Liang; Xiaojun Huang; Shaogui Wan; Jingliang Xing; Qichao Huang; Yefa Yang
Journal:  PLoS One       Date:  2014-04-09       Impact factor: 3.240

6.  Preferential expression of functional IL-17R in glioma stem cells: potential role in self-renewal.

Authors:  Prahlad Parajuli; Rohit Anand; Chandramouli Mandalaparty; Raviteja Suryadevara; Preethi U Sriranga; Sharon K Michelhaugh; Simona Cazacu; Susan Finniss; Archana Thakur; Lawrence G Lum; Dana Schalk; Chaya Brodie; Sandeep Mittal
Journal:  Oncotarget       Date:  2016-02-02

7.  Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells.

Authors:  Sarmistha Talukdar; Swadesh K Das; Anjan K Pradhan; Luni Emdad; Xue-Ning Shen; Jolene J Windle; Devanand Sarkar; Paul B Fisher
Journal:  Oncotarget       Date:  2016-08-23

8.  Melatonin Inhibits Glioblastoma Stem-like cells through Suppression of EZH2-NOTCH1 Signaling Axis.

Authors:  Xiangrong Zheng; Bo Pang; Guangyan Gu; Taihong Gao; Rui Zhang; Qi Pang; Qian Liu
Journal:  Int J Biol Sci       Date:  2017-02-06       Impact factor: 6.580

9.  Ezh2-mediated epigenetic modification is required for allogeneic T cell-induced lupus disease.

Authors:  Yuxuan Zhen; Roger D Smith; Fred D Finkelman; Wen-Hai Shao
Journal:  Arthritis Res Ther       Date:  2020-06-05       Impact factor: 5.156

Review 10.  Deubiquitinating Enzymes Orchestrate the Cancer Stem Cell-Immunosuppressive Niche Dialogue: New Perspectives and Therapeutic Potential.

Authors:  Jun-Nan Guo; Bai-Rong Xia; Shen-Hui Deng; Chang Yang; Ya-Nan Pi; Bin-Bin Cui; Wei-Lin Jin
Journal:  Front Cell Dev Biol       Date:  2021-06-09
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