| Literature DB >> 23763943 |
Ahmed M Elsharkawy1, Ulrich Schwab, Brendan McCarron, Alastair D Burt, Ann K Daly, Mark Hudson, Steven Masson.
Abstract
Highly active antiretroviral therapy has revolutionised HIV management. However, many of these drugs are potentially hepatotoxic. Here, we report the first adult case of efavirenz induced acute liver failure successfully treated by liver transplantation. Furthermore, genetic analysis revealed our patient to be a slow efavirenz metaboliser, contributing to the severity of clinical presentation.Entities:
Keywords: ALF; ALP; ALT; Acute liver failure; CMV; CYP2B6; DILI; Drug induced liver injury; EFV; Efavirenz; HAART; HCV; HIV; Liver transplantation; NNRTI; NRTI; OLT; TDM; acute liver failure; alanine aminotransferase; alkaline phosphatase; cytomegalovirus; drug induced liver injury; efavirenz; hepatitis C virus; highly active antiretroviral therapy; human immunodeficiency virus; non-nucleoside reverse transcriptase inhibitor; nucleoside reverse transcriptase inhibitor; orthotopic liver transplantation; therapeutic drug monitoring
Mesh：
Substances：
Year: 2013 PMID： 23763943 DOI： 10.1016/j.jcv.2013.05.003
Source DB: PubMed Journal: J Clin Virol ISSN： 1386-6532 Impact factor: 3.168