| Literature DB >> 23763766 |
Stephanie F Glineur1, Randall W Renshaw, Caroline M Percopo, Kimberly D Dyer, Edward J Dubovi, Joseph B Domachowske, Helene F Rosenberg.
Abstract
A previous report of a novel pneumovirus (PnV) isolated from the respiratory tract of a dog described its significant homology to the rodent pathogen, pneumonia virus of mice (PVM). The original PnV-Ane4 pathogen replicated in and could be re-isolated in infectious state from mouse lung but elicited minimal mortality compared to PVM strain J3666. Here we assess phylogeny and physiologic responses to 10 new PnV isolates. The G/glycoprotein sequences of all PnVs include elongated amino-termini when compared to the characterized PVMs, and suggest division into groups A and B. While we observed significant differences in cytokine production and neutrophil recruitment to the lungs of BALB/c mice in response to survival doses (50 TCID50 units) of representative group A (114378-10-29-KY-F) and group B (7968-11-OK) PnVs, we observed no evidence for positive selection (dN > dS) among the PnV/PnV, PVM/PnV or PVM/PVM G/glycoprotein or F/fusion protein sequence pairs. Published by Elsevier Inc.Entities:
Keywords: Chemokine; Inflammation; Neutrophil; Type I interferon
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Year: 2013 PMID： 23763766 PMCID： PMC3722285 DOI： 10.1016/j.virol.2013.05.011
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616