Dian-Hong Xu1, Ya-Si Huang, Dong-Qing Jiang, Ke Yuan. 1. The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, Lin'an, China.
Abstract
CONTEXT: Hyptis suaveolens (Linn.) Poit., Hyptis rhomboidea Mart. et Gal., and Hyptis brevipes Poit., are three species of Hyptis Jacq. (Lamiaceae). Hyptis suaveolens is used for the treatment of fever, headache, gastrointestinal bloating and rheumatism in the traditional folk medicine; Hyptis rhomboidea for hepatitis, ulcer and swollen poison; and Hyptis brevipes for asthma and malaria. OBJECTIVE: To characterize chemical compositions of the oils from three Hyptis species and evaluate their potential antimicrobial, radical scavenging activities and toxicities against brine shrimp. MATERIALS AND METHODS: The oils were obtained by hydrodistillation, and their chemical compositions were investigated by gas chromatography-mass spectrometry (GC-MS). Minimum inhibitory concentrations (MICs) were determined using the tube double-dilution technique. The antioxidant activities were investigated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay and toxicities by the brine shrimp bioassay. RESULTS: Forty-seven, 33 and 28 constituents of oils isolated, respectively, from H. suaveolens, H. rhomboidea and H. brevipes were identified. Among the essential oils, the strongest antioxidant activity was exhibited by H. brevipes with an SC₅₀ value of 2.019 ± 0.25 μg mL⁻¹. The H. brevipes oil exhibited the strongest antimicrobial activity (3.125-6.25 μg mL⁻¹) on pathogens employed in the assay. They all showed significant toxicities with median lethal concentration (LC₅₀) values of 62.2 ± 3.07 μg mL⁻¹, 65.9 ± 6.55 μg mL⁻¹ and 60.8 ± 9.04 μg mL⁻¹, respectively. DISCUSSION AND CONCLUSIONS: The three Hyptis species oils possess strong antimicrobial activities and toxicities. Hyptis rhomboidea and H. brevipes showed considerable antioxidant activity compared to the positive control.
CONTEXT: Hyptis suaveolens (Linn.) Poit., Hyptis rhomboidea Mart. et Gal., and Hyptis brevipes Poit., are three species of Hyptis Jacq. (Lamiaceae). Hyptis suaveolens is used for the treatment of fever, headache, gastrointestinal bloating and rheumatism in the traditional folk medicine; Hyptis rhomboidea for hepatitis, ulcer and swollen poison; and Hyptis brevipes for asthma and malaria. OBJECTIVE: To characterize chemical compositions of the oils from three Hyptis species and evaluate their potential antimicrobial, radical scavenging activities and toxicities against brine shrimp. MATERIALS AND METHODS: The oils were obtained by hydrodistillation, and their chemical compositions were investigated by gas chromatography-mass spectrometry (GC-MS). Minimum inhibitory concentrations (MICs) were determined using the tube double-dilution technique. The antioxidant activities were investigated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay and toxicities by the brine shrimp bioassay. RESULTS: Forty-seven, 33 and 28 constituents of oils isolated, respectively, from H. suaveolens, H. rhomboidea and H. brevipes were identified. Among the essential oils, the strongest antioxidant activity was exhibited by H. brevipes with an SC₅₀ value of 2.019 ± 0.25 μg mL⁻¹. The H. brevipes oil exhibited the strongest antimicrobial activity (3.125-6.25 μg mL⁻¹) on pathogens employed in the assay. They all showed significant toxicities with median lethal concentration (LC₅₀) values of 62.2 ± 3.07 μg mL⁻¹, 65.9 ± 6.55 μg mL⁻¹ and 60.8 ± 9.04 μg mL⁻¹, respectively. DISCUSSION AND CONCLUSIONS: The three Hyptis species oils possess strong antimicrobial activities and toxicities. Hyptis rhomboidea and H. brevipes showed considerable antioxidant activity compared to the positive control.
Authors: A N Coelho-de-Souza; R Alves-Soares; H D Oliveira; Y A Gomes-Vasconcelos; P J C Souza; T Santos-Nascimento; K A Oliveira; L R L Diniz; J Guimarães-Pereira; J H Leal-Cardoso Journal: Braz J Med Biol Res Date: 2021-01-25 Impact factor: 2.590
Authors: José Weverton Almeida-Bezerra; Felicidade Caroline Rodrigues; José Jailson Lima Bezerra; Anderson Angel Vieira Pinheiro; Saulo Almeida de Menezes; Aline Belém Tavares; Adrielle Rodrigues Costa; Priscilla Augusta de Sousa Fernandes; Viviane Bezerra da Silva; José Galberto Martins da Costa; Rafael Pereira da Cruz; Maria Flaviana Bezerra Morais-Braga; Henrique Douglas Melo Coutinho; Edward Teixeira de Albergaria; Marcos Vinicius Meiado; Abolghasem Siyadatpanah; Bonglee Kim; Antônio Fernando Morais de Oliveira Journal: Evid Based Complement Alternat Med Date: 2022-03-10 Impact factor: 2.629