Literature DB >> 23763376

Effects of biological sex on the pathophysiology of the heart.

Loubina Fazal1, Feriel Azibani, Nicolas Vodovar, Alain Cohen Solal, Claude Delcayre, Jane-Lise Samuel.   

Abstract

Cardiovascular diseases are the leading causes of death in men and women in industrialized countries. While the effects of biological sex on cardiovascular pathophysiology have long been known, the sex-specific mechanisms mediating these processes have been further elucidated over recent years. This review aims at analysing the sex-based differences in cardiac structure and function in adult mammals, and the sex-based differences in the main molecular mechanisms involved in the response of the heart to pathological situations. It emerged from this review that the sex-based difference is a variable that should be dealt with, not only in basic science or clinical research, but also with regards to therapeutic approaches.
© 2013 The British Pharmacological Society.

Entities:  

Keywords:  cardiac failure; gender; heart; hypertrophy

Mesh:

Substances:

Year:  2014        PMID: 23763376      PMCID: PMC3969072          DOI: 10.1111/bph.12279

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN: 0007-1188            Impact factor:   8.739


  125 in total

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5.  Gender-specific differences of cardiac remodeling in subjects with left ventricular dysfunction: a population-based study.

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Review 7.  Rapid activation of endothelial NO synthase by estrogen: evidence for a steroid receptor fast-action complex (SRFC) in caveolae.

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5.  Impact of the left ventricular mass index on the outcomes of severe aortic stenosis.

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