| Literature DB >> 2376278 |
B Maria1, F Stampf, A Goepp, C Dubois.
Abstract
Termination of early pregnancy (less than 49 days of amenorrhea) was induced in 75 patients with the combination of the antigestagen mifepristone and a prostaglandin analogue, meteneprost. After 48 h a single oral dose of 600 mg of mifepristone was followed by a 10 mg meteneprost vaginal pessary. Pregnancy was confirmed by clinical and ultrasound examinations and plasma HCG assessment. Complete abortion occurred in 72 patients (96%) and the three others required a surgical uterine aspiration. Bleeding continued for 4 to 12 days (mean = 8). Uterine pain and side effects occurred during the 3 h following the use of prostaglandin. Only minor analgesic were required in 30 patients. The combination of mifepristone and meteneprost is a safe and effective method to terminate an early pregnancy.Entities:
Keywords: Abortion, Induced; Biology; Bleeding; Contraception; Contraceptive Usage; Developed Countries; Diseases; Endocrine System; Europe; Examinations And Diagnoses; Family Planning; Fertility Control, Postconception; France; Gonadotropins; Gonadotropins, Chorionic--analysis; Hemic System; Hemoglobin Level--analysis; Hormones; Incidence; Laboratory Examinations And Diagnoses; Measurement; Mediterranean Countries; Method Acceptability; Physiology; Pregnancy; Pregnancy, First Trimester; Prostaglandins--administraction and dosage; Prostaglandins--side effects; Reproduction; Research Methodology; Signs And Symptoms; Western Europe
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Year: 1990 PMID： 2376278 DOI： 10.1016/0028-2243(90)90092-f
Source DB: PubMed Journal: Eur J Obstet Gynecol Reprod Biol ISSN： 0301-2115 Impact factor: 2.435