Literature DB >> 23761662

In vitro assessment of the immunological significance of a human monoclonal antibody directed to the influenza a virus nucleoprotein.

Rogier Bodewes1, Martina M Geelhoed-Mieras, Jens Wrammert, Rafi Ahmed, Patrick C Wilson, Ron A M Fouchier, Albert D M E Osterhaus, Guus F Rimmelzwaan.   

Abstract

Influenza A viruses cause annual epidemics and occasionally pandemics. Antibodies directed to the conserved viral nucleoprotein (NP) may play a role in immunity against various influenza A virus subtypes. Here, we assessed the immunological significance of a human monoclonal antibody directed to NP in vitro. This antibody bound to virus-infected cells but did not display virus-neutralizing activity, complement-dependent cell cytotoxicity, or opsonization of viral antigen for improved antigen presentation to CD8(+) T cells by dendritic cells.

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Year:  2013        PMID： 23761662      PMCID： PMC3754521          DOI： 10.1128/CVI.00339-13

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


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