Literature DB >> 23761511

Altered mental status and complete heart block: an unusual presentation of aspirin toxicity.

Nidhi Aggarwal1, Yizhak Kupfer, Kabu Chawla, Sidney Tessler.   

Abstract

Aspirin is one of the most commonly used medications. We report a patient who presented with severe weakness, altered mental status and complete heart block requiring temporary pacing. Despite the patient's family denying that the patient used aspirin, an arterial blood gas that revealed a respiratory alkalosis and metabolic acidosis suggested the diagnosis of salicylate toxicity. The salicylate level was extremely elevated and the patient was successfully treated with haemodialysis. Our case illustrates that salicylate toxicity should be considered in a patient with a combined metabolic acidosis and respiratory alkalosis. A prompt salicylate level should be obtained. This is also the first case of salicylate toxicity causing complete heart block in an adult. The heart block resolved with treatment of the salicylate toxicity.

Entities:  

Mesh:

Substances:

Year:  2013        PMID: 23761511      PMCID: PMC3703023          DOI: 10.1136/bcr-2013-010083

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  7 in total

1.  Acute cerebral white matter damage in lethal salicylate intoxication.

Authors:  Helmut Rauschka; Fahmy Aboul-Enein; Jan Bauer; Hans Nobis; Hans Lassmann; Manfred Schmidbauer
Journal:  Neurotoxicology       Date:  2006-07-13       Impact factor: 4.294

2.  Salicylate-induced delirium.

Authors:  T E Steele; W A Morton
Journal:  Psychosomatics       Date:  1986-06       Impact factor: 2.386

3.  Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey.

Authors:  David W Kaufman; Judith P Kelly; Lynn Rosenberg; Theresa E Anderson; Allen A Mitchell
Journal:  JAMA       Date:  2002-01-16       Impact factor: 56.272

Review 4.  Emergency department management of the salicylate-poisoned patient.

Authors:  Gerald F O'Malley
Journal:  Emerg Med Clin North Am       Date:  2007-05       Impact factor: 2.264

5.  Non-fatal ventricular dysrhythmias associated with severe salicylate toxicity.

Authors:  Kristen Kent; Michael Ganetsky; Jason Cohen; Steven Bird
Journal:  Clin Toxicol (Phila)       Date:  2008-04       Impact factor: 4.467

6.  Cardiac conduction abnormalities and atrial arrhythmias associated with salicylate toxicity.

Authors:  V Mukerji; M A Alpert; G C Flaker; C L Beach; R D Weber
Journal:  Pharmacotherapy       Date:  1986 Jan-Feb       Impact factor: 4.705

7.  Acute and chronic effects of aspirin toxicity and their treatment.

Authors:  A R Temple
Journal:  Arch Intern Med       Date:  1981-02-23
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.