| Literature DB >> 23761408 |
Victor Max Corman1, Andrea Rasche2,1, Thierno Diawo Diallo1, Veronika M Cottontail3, Andreas Stöcker4, Breno Frederico de Carvalho Dominguez Souza4, Jefferson Ivan Corrêa4, Aroldo José Borges Carneiro5, Carlos Roberto Franke5, Martina Nagy6, Markus Metz7, Mirjam Knörnschild3, Elisabeth K V Kalko8,3, Simon J Ghanem9, Karen D Sibaja Morales10, Egoitz Salsamendi11,3, Manuel Spínola10, Georg Herrler2, Christian C Voigt9, Marco Tschapka8,3, Christian Drosten1, Jan Felix Drexler1.
Abstract
Bats host a broad diversity of coronaviruses (CoVs), including close relatives of human pathogens. There is only limited data on neotropical bat CoVs. We analysed faecal, blood and intestine specimens from 1562 bats sampled in Costa Rica, Panama, Ecuador and Brazil for CoVs by broad-range PCR. CoV RNA was detected in 50 bats representing nine different species, both frugivorous and insectivorous. These bat CoVs were unrelated to known human or animal pathogens, indicating an absence of recent zoonotic spill-over events. Based on RNA-dependent RNA polymerase (RdRp)-based grouping units (RGUs) as a surrogate for CoV species identification, the 50 viruses represented five different alphacoronavirus RGUs and two betacoronavirus RGUs. Closely related alphacoronaviruses were detected in Carollia perspicillata and C. brevicauda across a geographical distance exceeding 5600 km. Our study expands the knowledge on CoV diversity in neotropical bats and emphasizes the association of distinct CoVs and bat host genera.Entities:
Mesh：
Substances：
Year: 2013 PMID： 23761408 DOI： 10.1099/vir.0.054841-0
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891