H Liu1, J Wu, S Xue, Q Zhang, Y Ruan, X Sun, S Xia. 1. University Department of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Abstract
OBJECTIVES: To compare the safety and efficacy of conventional monopolar transurethral resection of bladder tumour (TURBT) and 2-micron continuous-wave laser resection (2-µm laser) techniques in the management of multiple nonmuscle-invasive bladder cancer (NMIBC), and to investigate long-term effects on tumour recurrence. METHODS:Patients with multiple NMIBC were randomized to receive TURBT or 2-µm laser in a nonblinded manner. All patients received intravesical chemotherapy with epirubicin (40 mg/40 ml) for 8 weeks, beginning 1 week after surgery, followed with monthly maintenance therapy for 12 months. Three-year follow-up data of preoperative, operative and postoperative management were recorded. RESULTS: In total, 120 patients were included: 56 in the TURBT group and 64 in the 2-µm laser group. Intra- and postoperative complications (including bladder perforation, bleeding and irritation) were less frequently observed in the 2-µm laser group compared with the TURBT group. There were no significant differences in first time to recurrence, overall recurrence or occurrence of urethral strictures. CONCLUSIONS: The 2-µm laser resection method was more effective than TURBT in reducing rates of intra- and postoperative complications, but offered no additional benefit regarding tumour recurrence.
RCT Entities:
OBJECTIVES: To compare the safety and efficacy of conventional monopolar transurethral resection of bladder tumour (TURBT) and 2-micron continuous-wave laser resection (2-µm laser) techniques in the management of multiple nonmuscle-invasive bladder cancer (NMIBC), and to investigate long-term effects on tumour recurrence. METHODS:Patients with multiple NMIBC were randomized to receive TURBT or 2-µm laser in a nonblinded manner. All patients received intravesical chemotherapy with epirubicin (40 mg/40 ml) for 8 weeks, beginning 1 week after surgery, followed with monthly maintenance therapy for 12 months. Three-year follow-up data of preoperative, operative and postoperative management were recorded. RESULTS: In total, 120 patients were included: 56 in the TURBT group and 64 in the 2-µm laser group. Intra- and postoperative complications (including bladder perforation, bleeding and irritation) were less frequently observed in the 2-µm laser group compared with the TURBT group. There were no significant differences in first time to recurrence, overall recurrence or occurrence of urethral strictures. CONCLUSIONS: The 2-µm laser resection method was more effective than TURBT in reducing rates of intra- and postoperative complications, but offered no additional benefit regarding tumour recurrence.
Authors: Mario W Kramer; Jens J Rassweiler; Jan Klein; Alexey Martov; Nikolay Baykov; Lukas Lusuardi; Günter Janetschek; Rodolfo Hurle; Mathias Wolters; Mahmoud Abbas; Christoph A von Klot; Armin Leitenberger; Markus Riedl; Udo Nagele; Axel S Merseburger; Markus A Kuczyk; Marko Babjuk; Thomas R W Herrmann Journal: World J Urol Date: 2015-04-25 Impact factor: 4.226
Authors: Mario W Kramer; Mathias Wolters; Hannes Cash; Stephan Jutzi; Florian Imkamp; Markus A Kuczyk; Axel S Merseburger; Thomas R W Herrmann Journal: World J Urol Date: 2014-06-17 Impact factor: 4.226