PURPOSE: To evaluate stage IIA colorectal cancer in terms of recurrence so as to discover whether high preoperative serum carcinoembryonic antigen (s-CEA) levels indicate that the patient should be included in a high-risk group in stage II colorectal cancer. METHODS: We retrospectively reviewed the records of 1543 patients with stage IIA colorectal cancer who underwent curative surgery between January 2000 and December 2007. RESULTS: The 5-year disease-free survival and overall survival rates were significantly lower in patients with a higher than normal preoperative s-CEA (90.5% vs. 82.5%, P<0.001, and 92.4% vs. 87.8%, P=0.034, respectively). Multivariate analysis revealed that elevated preoperative s-CEA level, preoperative obstruction, rectal cancer, and dissection of fewer than 12 nodes were independent statistically significant prognostic factors that predicted disease-free survival in patients with stage IIA disease after curative resection. CONCLUSIONS: Elevated preoperative s-CEA concentration is a reliable predictor of recurrence after curative resection in patients with stage IIA colorectal cancer. Patients with stage IIA disease with elevated preoperative s-CEA level do worse than those with normal levels and might constitute a group to evaluate for adjuvant chemotherapy. Further studies on the effect of adjuvant chemotherapy in this group are needed.
PURPOSE: To evaluate stage IIA colorectal cancer in terms of recurrence so as to discover whether high preoperative serum carcinoembryonic antigen (s-CEA) levels indicate that the patient should be included in a high-risk group in stage II colorectal cancer. METHODS: We retrospectively reviewed the records of 1543 patients with stage IIA colorectal cancer who underwent curative surgery between January 2000 and December 2007. RESULTS: The 5-year disease-free survival and overall survival rates were significantly lower in patients with a higher than normal preoperative s-CEA (90.5% vs. 82.5%, P<0.001, and 92.4% vs. 87.8%, P=0.034, respectively). Multivariate analysis revealed that elevated preoperative s-CEA level, preoperative obstruction, rectal cancer, and dissection of fewer than 12 nodes were independent statistically significant prognostic factors that predicted disease-free survival in patients with stage IIA disease after curative resection. CONCLUSIONS: Elevated preoperative s-CEA concentration is a reliable predictor of recurrence after curative resection in patients with stage IIA colorectal cancer. Patients with stage IIA disease with elevated preoperative s-CEA level do worse than those with normal levels and might constitute a group to evaluate for adjuvant chemotherapy. Further studies on the effect of adjuvant chemotherapy in this group are needed.
Authors: Daniel P Nussbaum; Paul J Speicher; Asvin M Ganapathi; Brian R Englum; Jeffrey E Keenan; Christopher R Mantyh; John Migaly Journal: J Gastrointest Surg Date: 2014-08-05 Impact factor: 3.452
Authors: Han-Gil Kim; Seung Yoon Yang; Yoon Dae Han; Min Soo Cho; Byung Soh Min; Kang Young Lee; Nam Kyu Kim; Hyuk Hur Journal: PLoS One Date: 2021-06-09 Impact factor: 3.240
Authors: Won Kyung Cho; Doo Ho Choi; Hee Chul Park; Won Park; Jeong Il Yu; Young Suk Park; Joon Oh Park; Ho Yeong Lim; Won Ki Kang; Hee Cheol Kim; Yong Beom Cho; Seong Hyeon Yun; Woo Yong Lee Journal: Oncotarget Date: 2017-11-18
Authors: Tsuyoshi Konishi; Yoshifumi Shimada; Meier Hsu; Lauren Tufts; Rosa Jimenez-Rodriguez; Andrea Cercek; Rona Yaeger; Leonard Saltz; J Joshua Smith; Garrett M Nash; José G Guillem; Philip B Paty; Julio Garcia-Aguilar; Mithat Gonen; Martin R Weiser Journal: JAMA Oncol Date: 2018-03-01 Impact factor: 31.777