Maxim Terekhov1, Alexander Scholz, Laura M Schreiber. 1. Department of Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany, terekhov@uni-mainz.de.
Abstract
OBJECT: We present a pilot study based on (19)F-MRI to measure fast and slow wash-in and wash-out kinetics of volatile anesthetics in pig brain. METHOD: The periodic administration of anesthetics in pulsed mode is used to enhance the sensitivity of the anesthetic concentration detection by (19)F-MRI signal. Temporal correlation analysis allows mapping the kinetics time constants. RESULTS: The clear correlation response to anesthetics concentration changes was found in the brain region in comparison with fatty tissues. CONCLUSION: The methodology may yield important pharmacological findings on regional effect of the anesthetics in brain and be a step towards human studies.
OBJECT: We present a pilot study based on (19)F-MRI to measure fast and slow wash-in and wash-out kinetics of volatile anesthetics in pig brain. METHOD: The periodic administration of anesthetics in pulsed mode is used to enhance the sensitivity of the anesthetic concentration detection by (19)F-MRI signal. Temporal correlation analysis allows mapping the kinetics time constants. RESULTS: The clear correlation response to anesthetics concentration changes was found in the brain region in comparison with fatty tissues. CONCLUSION: The methodology may yield important pharmacological findings on regional effect of the anesthetics in brain and be a step towards human studies.
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