Literature DB >> 23760252

Infection with feline immunodeficiency virus directly activates CD4+ CD25+ T regulatory cells.

Michelle M Miller1, Jonathan E Fogle, Mary B Tompkins.   

Abstract

Lentivirus infection activates CD4(+) CD25(+) T regulatory (Treg) cells. Activation of Treg cells may be due to direct virus infection or chronic antigenic stimulation. Herein we demonstrate that in vitro feline immunodeficiency virus (FIV) infection, but not UV-inactivated virus, activates Treg cells as measured by immunosuppressive function and upregulation of GARP, FoxP3, and membrane-bound transforming growth factor β (TGF-β). These data demonstrate for the first time that AIDS lentiviruses infect and activate Treg cells, potentially contributing to immune dysfunction.

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Year:  2013        PMID： 23760252      PMCID： PMC3754053          DOI： 10.1128/JVI.00996-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  19 in total

1.  Cutting edge: allogeneic CD4+CD25+Foxp3+ T regulatory cells suppress autoimmunity while establishing transplantation tolerance.

Authors:  Dennis Adeegbe; Allison L Bayer; Robert B Levy; Thomas R Malek
Journal:  J Immunol       Date:  2006-06-15       Impact factor: 5.422

2.  Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors.

Authors:  Anjali Joshi; Himanshu Garg; Mary B Tompkins; Wayne A Tompkins
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

3.  Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection.

Authors:  Jacob D Estes; Stephen Wietgrefe; Timothy Schacker; Peter Southern; Greg Beilman; Cavan Reilly; Jeffrey M Milush; Jeffrey D Lifson; Donald L Sodora; John V Carlis; Ashley T Haase
Journal:  J Infect Dis       Date:  2007-01-08       Impact factor: 5.226

4.  The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients.

Authors:  Jan Andersson; Adriano Boasso; Jakob Nilsson; Rui Zhang; Norah J Shire; Stefan Lindback; Gene M Shearer; Claire A Chougnet
Journal:  J Immunol       Date:  2005-03-15       Impact factor: 5.422

5.  Feline glycoprotein A repetitions predominant anchors transforming growth factor beta on the surface of activated CD4(+)CD25(+) regulatory T cells and mediates AIDS lentivirus-induced T cell immunodeficiency.

Authors:  Michelle M Miller; Jonathan E Fogle; Peter Ross; Mary B Tompkins
Journal:  AIDS Res Hum Retroviruses       Date:  2013-02-01       Impact factor: 2.205

6.  Preferential replication of FIV in activated CD4(+)CD25(+)T cells independent of cellular proliferation.

Authors:  Anjali Joshi; Thomas W Vahlenkamp; Himanshu Garg; Wayne A F Tompkins; Mary B Tompkins
Journal:  Virology       Date:  2004-04-10       Impact factor: 3.616

7.  TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.

Authors:  Kazuhiko Nakamura; Atsushi Kitani; Ivan Fuss; Aasta Pedersen; Naohiko Harada; Hajime Nawata; Warren Strober
Journal:  J Immunol       Date:  2004-01-15       Impact factor: 5.422

8.  Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4+CD25+ T regulatory cells.

Authors:  Thomas W Vahlenkamp; Mary B Tompkins; Wayne A F Tompkins
Journal:  J Immunol       Date:  2004-04-15       Impact factor: 5.422

9.  Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta.

Authors:  K Nakamura; A Kitani; W Strober
Journal:  J Exp Med       Date:  2001-09-03       Impact factor: 14.307

10.  HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells.

Authors:  Kyra Oswald-Richter; Stacy M Grill; Nikki Shariat; Mindy Leelawong; Mark S Sundrud; David W Haas; Derya Unutmaz
Journal:  PLoS Biol       Date:  2004-07-13       Impact factor: 8.029
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  9 in total

1.  Investigation of immune cell markers in feline oral squamous cell carcinoma.

Authors:  Ellen E Sparger; Brian G Murphy; Farina Mustaffa Kamal; Boaz Arzi; Diane Naydan; Chrisoula T Skouritakis; Darren P Cox; Katherine Skorupski
Journal:  Vet Immunol Immunopathol       Date:  2018-06-13       Impact factor: 2.046

Review 2.  Neurologic disease in feline immunodeficiency virus infection: disease mechanisms and therapeutic interventions for NeuroAIDS.

Authors:  Christopher Power
Journal:  J Neurovirol       Date:  2017-12-15       Impact factor: 2.643

3.  Changes of CD4+CD25+ cells ratio in immune organs from chickens challenged with infectious bursal disease virus strains with varying virulences.

Authors:  Xiaoxue Yu; Lei Rui; Qiang Shao; Haiwen Liu; Yanan Lu; Yongchao Zhang; Zandong Li
Journal:  Viruses       Date:  2015-03-20       Impact factor: 5.048

Review 4.  Applications of the FIV Model to Study HIV Pathogenesis.

Authors:  Craig Miller; Zaid Abdo; Aaron Ericsson; John Elder; Sue VandeWoude
Journal:  Viruses       Date:  2018-04-20       Impact factor: 5.048

5.  Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis.

Authors:  Luisa Helena Monteiro de Miranda; Marina Meli; Fátima Conceição-Silva; Marilisa Novacco; Rodrigo Caldas Menezes; Sandro Antonio Pereira; Sarah Sugiarto; Érica Guerino Dos Reis; Isabella Dib Ferreira Gremião; Regina Hofmann-Lehmann
Journal:  PLoS One       Date:  2018-11-30       Impact factor: 3.240

6.  Immunopathologic Effects of Prednisolone and Cyclosporine A on Feline Immunodeficiency Virus Replication and Persistence.

Authors:  Craig Miller; Jordan Powers; Esther Musselman; Ryan Mackie; John Elder; Sue VandeWoude
Journal:  Viruses       Date:  2019-08-30       Impact factor: 5.048

Review 7.  Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy.

Authors:  Jagadeesh Bayry
Journal:  Virusdisease       Date:  2013-11-29

8.  Micro-RNA 10a Is Increased in Feline T Regulatory Cells and Increases Foxp3 Protein Expression Following In Vitro Transfection.

Authors:  Yan Wang; Mukta Nag; Joanne L Tuohy; Jonathan E Fogle
Journal:  Vet Sci       Date:  2017-02-21

Review 9.  Feline Immunodeficiency Virus Neuropathogenesis: A Model for HIV-Induced CNS Inflammation and Neurodegeneration.

Authors:  Rick B Meeker; Lola Hudson
Journal:  Vet Sci       Date:  2017-03-06
  9 in total

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