OBJECTIVES: Acute respiratory distress syndrome develops commonly in critically ill patients in response to an injurious stimulus. The prevalence and risk factors for development of acute respiratory distress syndrome after spontaneous intracerebral hemorrhage have not been reported. We sought to determine the prevalence of acute respiratory distress syndrome after intracerebral hemorrhage, characterize risk factors for its development, and assess its impact on patient outcomes. DESIGN: Retrospective cohort study at two academic centers. PATIENTS: We included consecutive patients presenting from June 1, 2000, to November 1, 2010, with intracerebral hemorrhage requiring mechanical ventilation. We excluded patients with age less than 18 years, intracerebral hemorrhage secondary to trauma, tumor, ischemic stroke, or structural lesion; if they required intubation only during surgery; if they were admitted for comfort measures; or for a history of immunodeficiency. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Data were collected both prospectively as part of an ongoing cohort study and by retrospective chart review. Of 1,665 patients identified by database query, 697 met inclusion criteria. The prevalence of acute respiratory distress syndrome was 27%. In unadjusted analysis, high tidal volume ventilation was associated with an increased risk of acute respiratory distress syndrome (hazard ratio, 1.79 [95% CI, 1.13-2.83]), as were male sex, RBC and plasma transfusion, higher fluid balance, obesity, hypoxemia, acidosis, tobacco use, emergent hematoma evacuation, and vasopressor dependence. In multivariable modeling, high tidal volume ventilation was the strongest risk factor for acute respiratory distress syndrome development (hazard ratio, 1.74 [95% CI, 1.08-2.81]) and for inhospital mortality (hazard ratio, 2.52 [95% CI, 1.46-4.34]). CONCLUSIONS: Development of acute respiratory distress syndrome is common after intubation for intracerebral hemorrhage. Modifiable risk factors, including high tidal volume ventilation, are associated with its development and in-patient mortality.
OBJECTIVES:Acute respiratory distress syndrome develops commonly in critically illpatients in response to an injurious stimulus. The prevalence and risk factors for development of acute respiratory distress syndrome after spontaneous intracerebral hemorrhage have not been reported. We sought to determine the prevalence of acute respiratory distress syndrome after intracerebral hemorrhage, characterize risk factors for its development, and assess its impact on patient outcomes. DESIGN: Retrospective cohort study at two academic centers. PATIENTS: We included consecutive patients presenting from June 1, 2000, to November 1, 2010, with intracerebral hemorrhage requiring mechanical ventilation. We excluded patients with age less than 18 years, intracerebral hemorrhage secondary to trauma, tumor, ischemic stroke, or structural lesion; if they required intubation only during surgery; if they were admitted for comfort measures; or for a history of immunodeficiency. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Data were collected both prospectively as part of an ongoing cohort study and by retrospective chart review. Of 1,665 patients identified by database query, 697 met inclusion criteria. The prevalence of acute respiratory distress syndrome was 27%. In unadjusted analysis, high tidal volume ventilation was associated with an increased risk of acute respiratory distress syndrome (hazard ratio, 1.79 [95% CI, 1.13-2.83]), as were male sex, RBC and plasma transfusion, higher fluid balance, obesity, hypoxemia, acidosis, tobacco use, emergent hematoma evacuation, and vasopressor dependence. In multivariable modeling, high tidal volume ventilation was the strongest risk factor for acute respiratory distress syndrome development (hazard ratio, 1.74 [95% CI, 1.08-2.81]) and for inhospital mortality (hazard ratio, 2.52 [95% CI, 1.46-4.34]). CONCLUSIONS: Development of acute respiratory distress syndrome is common after intubation for intracerebral hemorrhage. Modifiable risk factors, including high tidal volume ventilation, are associated with its development and in-patient mortality.
Authors: Ognjen Gajic; Ousama Dabbagh; Pauline K Park; Adebola Adesanya; Steven Y Chang; Peter Hou; Harry Anderson; J Jason Hoth; Mark E Mikkelsen; Nina T Gentile; Michelle N Gong; Daniel Talmor; Ednan Bajwa; Timothy R Watkins; Emir Festic; Murat Yilmaz; Remzi Iscimen; David A Kaufman; Annette M Esper; Ruxana Sadikot; Ivor Douglas; Jonathan Sevransky; Michael Malinchoc Journal: Am J Respir Crit Care Med Date: 2010-08-27 Impact factor: 21.405
Authors: Carolyn S Calfee; Michael A Matthay; Mark D Eisner; Neal Benowitz; Mariah Call; Jean-François Pittet; Mitchell J Cohen Journal: Am J Respir Crit Care Med Date: 2011-03-18 Impact factor: 21.405
Authors: Robert E Hoesch; Eric Lin; Mark Young; Rebecca F Gottesman; Laith Altaweel; Paul A Nyquist; Robert D Stevens Journal: Crit Care Med Date: 2012-02 Impact factor: 7.598
Authors: Roy G Brower; Michael A Matthay; Alan Morris; David Schoenfeld; B Taylor Thompson; Arthur Wheeler Journal: N Engl J Med Date: 2000-05-04 Impact factor: 91.245
Authors: Hollis R O'Neal; Tatsuki Koyama; Elizabeth A S Koehler; Edward Siew; Blake R Curtis; Richard D Fremont; Addison K May; Gordon R Bernard; Lorraine B Ware Journal: Crit Care Med Date: 2011-06 Impact factor: 7.598
Authors: V Marco Ranieri; Gordon D Rubenfeld; B Taylor Thompson; Niall D Ferguson; Ellen Caldwell; Eddy Fan; Luigi Camporota; Arthur S Slutsky Journal: JAMA Date: 2012-06-20 Impact factor: 56.272
Authors: SeungHye Han; Greg S Martin; James P Maloney; Carl Shanholtz; Kathleen C Barnes; Stacey Murray; Jonathan E Sevransky Journal: Crit Care Date: 2011-11-01 Impact factor: 9.097
Authors: Antonia Koutsoukou; Maria Katsiari; Stylianos E Orfanos; Anastasia Kotanidou; Maria Daganou; Magdalini Kyriakopoulou; Nikolaos G Koulouris; Nikoletta Rovina Journal: World J Crit Care Med Date: 2016-02-04
Authors: Jeremy R Beitler; Tiffany Bita Ghafouri; Sayuri P Jinadasa; Ariel Mueller; Leeyen Hsu; Ryan J Anderson; Jisha Joshua; Sanjeev Tyagi; Atul Malhotra; Rebecca E Sell; Daniel Talmor Journal: Am J Respir Crit Care Med Date: 2017-05-01 Impact factor: 21.405
Authors: Karim Asehnoune; Ségolène Mrozek; Pierre François Perrigault; Philippe Seguin; Claire Dahyot-Fizelier; Sigismond Lasocki; Anne Pujol; Mathieu Martin; Russel Chabanne; Laurent Muller; Jean Luc Hanouz; Emmanuelle Hammad; Bertrand Rozec; Thomas Kerforne; Carole Ichai; Raphael Cinotti; Thomas Geeraerts; Djillali Elaroussi; Paolo Pelosi; Samir Jaber; Marie Dalichampt; Fanny Feuillet; Véronique Sebille; Antoine Roquilly Journal: Intensive Care Med Date: 2017-03-18 Impact factor: 17.440
Authors: Jonathan Elmer; David Yamane; Peter C Hou; Susan R Wilcox; Ednan K Bajwa; Dean R Hess; Carlos A Camargo; Steven M Greenberg; Jonathan Rosand; Daniel J Pallin; Joshua N Goldstein; Sukhjit S Takhar Journal: Neurocrit Care Date: 2017-02 Impact factor: 3.210
Authors: Marc Turon; Sol Fernández-Gonzalo; Candelaria de Haro; Rudys Magrans; Josefina López-Aguilar; Lluís Blanch Journal: Ann Transl Med Date: 2018-01
Authors: Ary Serpa Neto; Fabienne D Simonis; Carmen S V Barbas; Michelle Biehl; Rogier M Determann; Jonathan Elmer; Gilberto Friedman; Ognjen Gajic; Joshua N Goldstein; Janneke Horn; Nicole P Juffermans; Rita Linko; Roselaine Pinheiro de Oliveira; Sugantha Sundar; Daniel Talmor; Esther K Wolthuis; Marcelo Gama de Abreu; Paolo Pelosi; Marcus J Schultz Journal: Intensive Care Med Date: 2014-05-09 Impact factor: 17.440