| Literature DB >> 2375988 |
Y Yasui1, D F Cechetto, C B Saper.
Abstract
Recent studies indicate that cholinergic innervation of the rostral ventrolateral medulla (RVL) may play an important role in regulation of blood pressure, but the origin of this input is not known. Using retrograde fluorescent tracing combined with immunohistochemistry for choline acetyltransferase, we found that as many as 10% of the cholinergic neurons in the pedunculopontine tegmental nucleus (PPT) can be retrogradely labeled from the RVL. Anterograde tracing of this pathway with PHA-L demonstrated that descending fibers from the region of the PPT ramify and give off terminal boutons in the RVL. These studies indicate that PPT may be a major source of cholinergic afferents to the RVL.Entities:
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Year: 1990 PMID： 2375988 DOI： 10.1016/0006-8993(90)91002-x
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252