Literature DB >> 23759653

A novel 5-way translocation t(9;11;13;19;22) in a case of chronic-phase chronic myeloid leukemia.

Shantashri Vaidya1, Dolly Joshi, Kanjaksha Ghosh, Prantar Chakrabarti, Babu Rao Vundinti.   

Abstract

Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder that occurs because of t(9;22)(q34;q11) translocations. Complex translocations have been reported in CML. We report a novel 5-way translocation 46,XY,t(9;11;13;19;22)(9q34.12;11p11.12;13q21.31;19q13.12;22q11.21) using GTG banding, fluorescence in situ hybridization, and spectral karyotyping in a case of chronic-phase CML. Molecular analysis revealed the presence of 2 types of transcripts (b3a2, b2a2). The patient was responding to the imatinib treatment. However, the patient needs to be carefully monitored at various intervals.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  5-Way translocation; BCR/ABL gene; Chronic myeloid leukemia; Chronic phase

Mesh：

Substances：

Year:  2013        PMID： 23759653     DOI： 10.1016/j.humpath.2013.02.021

Source DB:  PubMed          Journal:  Hum Pathol        ISSN： 0046-8177            Impact factor:   3.466


  5 in total

Review 1.  Spectral karyotyping: an unique technique for the detection of complex genomic rearrangements in leukemia.

Authors:  Bo Guo; Xiaoping Han; Zhanhe Wu; Wanming Da; Hongli Zhu
Journal:  Transl Pediatr       Date:  2014-04

Review 2.  New insights in cellular and molecular aspects of BM niche in chronic myelogenous leukemia.

Authors:  Saeid Shahrabi; Shirin Azizidoost; Mohammad Shahjahani; Fakher Rahim; Ahmad Ahmadzadeh; Najmaldin Saki
Journal:  Tumour Biol       Date:  2014-09-19

Review 3.  Role of tyrosine kinase inhibitor in chronic myeloid leukemia patients with SARS-CoV-2 infection: A narrative Review.

Authors:  Muhammad Asif; Muhammad Amir; Abrar Hussain; Niaz M Achakzai; Peter Natesan Pushparaj; Mahmood Rasool
Journal:  Medicine (Baltimore)       Date:  2022-07-01       Impact factor: 1.817

4.  Molecular, Cytogenetic, and Hematological Analysis of Chronic Myeloid Leukemia Patients and Discovery of Two Novel Translocations.

Authors:  Muhammad Asif; Abrar Hussain; Abdul Wali; Nazeer Ahmed; Irfan Ali; Zafar Iqbal; Muhammad Amir; Muhammad Shafiq; Mahmood Rasool
Journal:  Anal Cell Pathol (Amst)       Date:  2021-08-12       Impact factor: 2.916

5.  Saudi Arabian CML patient with a novel four-way translocation at t(9;22;5;2)(q34;q11.2;p13;q44).

Authors:  Walid Dridi; Solaf Kanfar; Patrick M A Sleiman; Yichuan Liu; Hakon Hakonarson; Hayaal Rammah; Alia Matrouk
Journal:  Mol Genet Genomic Med       Date:  2022-05-11       Impact factor: 2.473
  5 in total

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