Literature DB >> 23759565

Therapeutic S and G2 checkpoint override causes centromere fragmentation in mitosis.

Ailine Stolz1, Holger Bastians.   

Abstract

Entities:  

Keywords:  Chk1; UCN-01; anticancer therapy; centromere; checkpoints; gemcitabine; kinetochore; mitosis; replication; spindle assembly checkpoint; topoisomerase inhibitor

Mesh：

Year:  2013        PMID： 23759565      PMCID： PMC3735695          DOI： 10.4161/cc.25175

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


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  5 in total

1.  Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe.

Authors:  Archie N Tse; Gary K Schwartz
Journal:  Cancer Res       Date:  2004-09-15       Impact factor: 12.701

2.  Movement and segregation of kinetochores experimentally detached from mammalian chromosomes.

Authors:  B R Brinkley; R P Zinkowski; W L Mollon; F M Davis; M A Pisegna; M Pershouse; P N Rao
Journal:  Nature       Date:  1988-11-17       Impact factor: 49.962

3.  Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override.

Authors:  Neil Beeharry; Jerome B Rattner; Juliane P Caviston; Tim Yen
Journal:  Cell Cycle       Date:  2013-04-24       Impact factor: 4.534

4.  Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation.

Authors:  Celia Vogel; Christian Hager; Holger Bastians
Journal:  Cancer Res       Date:  2007-01-01       Impact factor: 12.701

5.  Fluorescence analysis of late DNA replication in mouse metaphase chromosomes using BUdR and 33258 Hoechst.

Authors:  K Madan; J W Allen; P S Gerald; S A Latt
Journal:  Exp Cell Res       Date:  1976-05       Impact factor: 3.905
  5 in total
  1 in total

1.  ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms.

Authors:  Harriet E D Southgate; Lindi Chen; Deborah A Tweddle; Nicola J Curtin
Journal:  Cancers (Basel)       Date:  2020-04-28       Impact factor: 6.639
  1 in total

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