Vinylcyclopropane derivatives in transition-metal-catalyzed cycloadditions for the synthesis of carbocyclic compounds.

Vinylcyclopropane (VCP) derivatives participate in a variety of transition-metal-catalyzed multicomponent cycloadditions to produce five- to eight-membered carbocycles. Various cycloaddition modes provide novel approaches to mono-, bi-, and polycyclic molecules. In this Synopsis, recent advances in transition-metal-catalyzed VCP cycloadditions are discussed, with a particular emphasis on the influence of VCP substitution pattern on cycloaddition modes. A tabular summary of applications of the VCP cycloadditions in natural product synthesis is also presented.