| Literature DB >> 23756190 |
Hong-Ling Wang1, Chang-An Geng, Yun-Bao Ma, Xue-Mei Zhang, Ji-Jun Chen.
Abstract
Three new secoiridoids, swermacrolactones A-C (1-3), together with fourteen known compounds were isolated from Swertia macrosperma. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, MS, 1D and 2D NMR). By anti-HBV assay on the Hep G 2.2.15 cell line in vitro, the most active compound, luteolin (9), inhibited the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 0.02 and 0.02 mM, respectively.Entities:
Keywords: Anti-HBV activity; Gentianaceae; Secoiridoids; Swermacrolactones A–C; Swertia macrosperma
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Year: 2013 PMID： 23756190 DOI： 10.1016/j.fitote.2013.06.002
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882