Literature DB >> 23752769

A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO).

Sara Piccinonna1, Nicola Margiotta, Nunzio Denora, Rosa Maria Iacobazzi, Concetta Pacifico, Giuseppe Trapani, Giovanni Natile.   

Abstract

A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new (99m)Tc or (188/186)Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac-[ReBr(CO)3(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.

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Year:  2013        PMID： 23752769     DOI： 10.1039/c3dt51152a

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  3 in total

1.  Synthesis, Characterization, and in Vitro Evaluation of a New TSPO-Selective Bifunctional Chelate Ligand.

Authors:  Nunzio Denora; Nicola Margiotta; Valentino Laquintana; Angela Lopedota; Annalisa Cutrignelli; Maurizio Losacco; Massimo Franco; Giovanni Natile
Journal:  ACS Med Chem Lett       Date:  2014-03-30       Impact factor: 4.345

2.  Synthesis and Evaluation of Tricarbonyl (99m)Tc-Labeled 2-(4-Chloro)phenyl-imidazo[1,2-a]pyridine Analogs as Novel SPECT Imaging Radiotracer for TSPO-Rich Cancer.

Authors:  Ji Young Choi; Rosa Maria Iacobazzi; Mara Perrone; Nicola Margiotta; Annalisa Cutrignelli; Jae Ho Jung; Do Dam Park; Byung Seok Moon; Nunzio Denora; Sang Eun Kim; Byung Chul Lee
Journal:  Int J Mol Sci       Date:  2016-07-07       Impact factor: 5.923

3.  Gold(I) Complexes with a Quinazoline Carboxamide Alkynyl Ligand: Synthesis, Cytotoxicity, and Mechanistic Studies.

Authors:  Leila Tabrizi; Won Seok Yang; Chetan Chintha; Liam Morrison; Afshin Samali; Joe W Ramos; Andrea Erxleben
Journal:  Eur J Inorg Chem       Date:  2021-05-11       Impact factor: 2.524
  3 in total

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