| Literature DB >> 23752513 |
Tzu-Wen Huang1, Jann-Tay Wang, Tsai-Ling Lauderdale, Tsai-Lien Liao, Jui-Fen Lai, Mei-Chen Tan, Ann-Chi Lin, Ying-Tsong Chen, Shih-Feng Tsai, Shan-Chwen Chang.
Abstract
Genetic determinants of a bla(NDM-1)-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX_NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a bla(NDM-1) gene in pKOX_NDM1 and two extended-spectrum β-lactamase producers (bla(CTX-M-3) and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrug-resistant bacterial infections and the potential danger of emerging resistant enterobacteria.Entities:
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Year: 2013 PMID: 23752513 PMCID: PMC3719732 DOI: 10.1128/AAC.02266-12
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191