Vlasta Merglová1, Daniel Hrušák2, Ludmila Boudová3, Petr Mukenšnabl3, Eva Valentová1, Lubor Hostička4. 1. Department of Dentistry (Head of Department: as. Prof. Dr. Antonin Zicha, CSc.), University Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60 Pilsen, Czech Republic. 2. Department of Oral and Maxillofacial Surgery (Head of Department: Dr. Daniel Hrusak, Ph.D.), University Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60 Pilsen, Czech Republic. Electronic address: hrusak@fnplzen.cz. 3. Sikl's Department of Pathology (Head of Department: Prof. Dr. Michal Michal), University Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Dr. Edvarda Benese 13, 305 99 Pilsen, Czech Republic. 4. Department of Oral and Maxillofacial Surgery (Head of Department: Dr. Daniel Hrusak, Ph.D.), University Hospital and Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
Abstract
BACKGROUND: Langerhans cell histiocytosis is a rare disease characterized by monoclonal proliferation and migration of special dendritic cells. This disease primarily affects bones, but occurs less frequently in other organ systems or may manifest as a multisystem disease. CASE REPORTS: Extraoral and intraoral symptoms of Langerhans cell histiocytosis are described in a 13-month-old female and a 5-month-old male infant. Dermatitis was found on the scalp, abdomen, flexures and in intertrigineous areas in both patients. The intraoral examination of the 13-month-old infant showed premature eruption of all maxillary deciduous molars, loosening and significant damage of periodontal tissues (gingivitis with bleeding, swelling of palatal mucosa, periodontal pockets) resembling severe periodontitis. In the oral cavity of the 5-month-old predentate infant bilateral swellings of maxillary alveolar mucosa with deep ulcerations were seen. The oral and skin symptoms in both infants were indications for biopsy. Langerhans cell histiocytosis was confirmed histologically and immunohistochemically. CONCLUSION: Oral findings in Langerhans cell histiocytosis may be the only clinical symptom of the disease; therefore the role of dentists in establishing diagnosis is very important.
BACKGROUND: Langerhans cell histiocytosis is a rare disease characterized by monoclonal proliferation and migration of special dendritic cells. This disease primarily affects bones, but occurs less frequently in other organ systems or may manifest as a multisystem disease. CASE REPORTS: Extraoral and intraoral symptoms of Langerhans cell histiocytosis are described in a 13-month-old female and a 5-month-old male infant. Dermatitis was found on the scalp, abdomen, flexures and in intertrigineous areas in both patients. The intraoral examination of the 13-month-old infant showed premature eruption of all maxillary deciduous molars, loosening and significant damage of periodontal tissues (gingivitis with bleeding, swelling of palatal mucosa, periodontal pockets) resembling severe periodontitis. In the oral cavity of the 5-month-old predentate infant bilateral swellings of maxillary alveolar mucosa with deep ulcerations were seen. The oral and skin symptoms in both infants were indications for biopsy. Langerhans cell histiocytosis was confirmed histologically and immunohistochemically. CONCLUSION: Oral findings in Langerhans cell histiocytosis may be the only clinical symptom of the disease; therefore the role of dentists in establishing diagnosis is very important.
Authors: Natália Rocha Bedran; Román Carlos; Bruno Augusto Benevenuto de Andrade; Ana Paula Silva Bueno; Mário José Romañach; Cristiane Bedran Milito Journal: Head Neck Pathol Date: 2017-11-21
Authors: Fábio Vieira de Miranda; William Phillip Pereira da Silva; Renato Victor de Oliveira; Gustavo Antônio Correia Momesso; Tárik Ocon Braga Polo; Leonardo Pérez Faverani Journal: Rev Bras Ter Intensiva Date: 2019-10-14