Mohammad Naderi1, Mohammad Hashemi2, Mohsen Taheri3, Hossein Pesarakli1, Ebrahim Eskandari-Nasab4, Gholamreza Bahari4. 1. Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. 2. Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Electronic address: mhd.hashemi@gmail.com. 3. Research Center of Genetics in Non-contagious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Genetics, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. 4. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Abstract
INTRODUCTION: The association between -336 A/G polymorphism of CD209 and susceptibility to/protection from tuberculosis is inconsistent. AIM: The present study aimed at evaluating the possible association between CD209 rs4804803 (-336 A/G) gene polymorphism and pulmonary tuberculosis (PTB) in a sample of Iranian population. MATERIALS AND METHODS: This case-control study was performed on 156 PTB patients and 154 healthy individuals. Tetra-amplification refractory mutation system-polymerase chain reaction was used to detect the polymorphisms. RESULTS: Our findings revealed that the CD209 rs4804803 increased the risk of PTB in codominant [odds ratio (OR) = 5.16, 95% confidence interval (CI) = 1.60-16.59, p = 0.006, GG vs. AA], dominant (OR = 1.69, 95% CI = 1.07-2.66, p = 0.024, AG + GG vs. AA), and recessive (OR = 4.20, 95% CI = 1.34-13.16, p = 0.014, GG vs. AA + AG) tested inheritance models. Furthermore, the rs4804803 G allele increased the risk of PTB (OR = 1.58, 95% CI = 1.12-2.23, p = 0.011) as compared to the A allele. CONCLUSION: Our data suggest that CD209 rs4804803 polymorphism increased the risk of PTB in a sample of Iranian population.
INTRODUCTION: The association between -336 A/G polymorphism of CD209 and susceptibility to/protection from tuberculosis is inconsistent. AIM: The present study aimed at evaluating the possible association between CD209rs4804803 (-336 A/G) gene polymorphism and pulmonary tuberculosis (PTB) in a sample of Iranian population. MATERIALS AND METHODS: This case-control study was performed on 156 PTB patients and 154 healthy individuals. Tetra-amplification refractory mutation system-polymerase chain reaction was used to detect the polymorphisms. RESULTS: Our findings revealed that the CD209rs4804803 increased the risk of PTB in codominant [odds ratio (OR) = 5.16, 95% confidence interval (CI) = 1.60-16.59, p = 0.006, GG vs. AA], dominant (OR = 1.69, 95% CI = 1.07-2.66, p = 0.024, AG + GG vs. AA), and recessive (OR = 4.20, 95% CI = 1.34-13.16, p = 0.014, GG vs. AA + AG) tested inheritance models. Furthermore, the rs4804803 G allele increased the risk of PTB (OR = 1.58, 95% CI = 1.12-2.23, p = 0.011) as compared to the A allele. CONCLUSION: Our data suggest that CD209rs4804803 polymorphism increased the risk of PTB in a sample of Iranian population.
Authors: Catherine M Stein; Lindsay Sausville; Christian Wejse; Rafal S Sobota; Nicola M Zetola; Philip C Hill; W Henry Boom; William K Scott; Giorgio Sirugo; Scott M Williams Journal: Curr Genet Med Rep Date: 2017-10-12
Authors: Olanrewaju B Morenikeji; Jessica L Metelski; Megan E Hawkes; Anna L Capria; Brooke N Seamans; Catherine O Falade; Olusola Ojurongbe; Bolaji N Thomas Journal: Microorganisms Date: 2020-01-23