| Literature DB >> 23749575 |
Jingbo Qiao1, Tu Hong, Honglian Guo, Ya-Qiong Xu, Dai H Chung.
Abstract
Small interfering RNA (siRNA) has the potential to influence gene expression with a high degree of target gene specificity. However, the clinical application of siRNA therapeutics has proven to be less promising as evidenced by its poor intracellular uptake, instability in vivo, and nonspecific immune stimulations. Recently, we have demonstrated that single-walled carbon nanotube (SWNT)-mediated siRNA delivery can enhance the efficiency of siRNA-mediated gastrin-releasing peptide receptor (GRP-R) gene silencing by stabilizing siRNA while selectively targeting tumor tissues. Based on our recent findings, we introduce a novel technique to silence specific gene(s) in human neuroblastoma through SWNT-mediated siRNA delivery in vitro and in vivo.Entities:
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Year: 2013 PMID： 23749575 PMCID： PMC4706374 DOI： 10.1007/978-1-62703-468-5_11
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745